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Attention Score in Context
| Title |
Longevity candidate genes and their association with personality traits in the elderly
|
|---|---|
| Published in |
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, December 2011
|
| DOI | 10.1002/ajmg.b.32013 |
| Pubmed ID | |
| Authors |
Michelle Luciano, Lorna M. Lopez, Marleen H.M. de Moor, Sarah E. Harris, Gail Davies, Teresa Nutile, Robert F. Krueger, Tõnu Esko, David Schlessinger, Tanaka Toshiko, Jaime L. Derringer, Anu Realo, Narelle K. Hansell, Michele L. Pergadia, Anu‐Katriina Pesonen, Serena Sanna, Antonio Terracciano, Pamela A.F. Madden, Brenda Penninx, Philip Spinhoven, Catherina A. Hartman, Ben A. Oostra, A. Cecile J.W. Janssens, Johan G. Eriksson, John M. Starr, Alessandra Cannas, Luigi Ferrucci, Andres Metspalu, Margeret J. Wright, Andrew C. Heath, Cornelia M. van Duijn, Laura J. Bierut, Katri Raikkonen, Nicholas G. Martin, Marina Ciullo, Dan Rujescu, Dorret I. Boomsma, Ian J. Deary |
| Abstract |
Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P < 0.0002), but there was an over-representation of nominally significant (P < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17,106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged >60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Japan | 1 | 2% |
| Unknown | 63 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 15% |
| Professor | 10 | 15% |
| Student > Ph. D. Student | 9 | 14% |
| Student > Master | 6 | 9% |
| Student > Bachelor | 5 | 8% |
| Other | 12 | 18% |
| Unknown | 14 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 23% |
| Psychology | 14 | 21% |
| Agricultural and Biological Sciences | 12 | 18% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Chemistry | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 15 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,277,187
of 25,411,814 outputs
Outputs from American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics
#424
of 1,158 outputs
Outputs of similar age
#70,650
of 249,637 outputs
Outputs of similar age from American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics
#8
of 21 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 1,158 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,637 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.