| Title |
Cutaneous Lupus Erythematosus: An Update on Pathogenesis, Diagnosis and Treatment
|
|---|---|
| Published in |
American Journal of Clinical Dermatology, February 2016
|
| DOI | 10.1007/s40257-016-0173-9 |
| Pubmed ID | |
| Authors |
Emily Z. Hejazi, Victoria P. Werth |
| Abstract |
Cutaneous lupus erythematosus (CLE) includes a broad range of dermatologic manifestations, which may or may not be associated with systemic disease. Recent studies in this area continue to shape our understanding of this disease and treatment options. Epidemiologic studies have found an incidence of CLE of 4.30 per 100,000, which approaches similar analysis for systemic lupus erythematosus (SLE). Although there have been extensive efforts to define SLE, the classification of CLE and its subgroups remains a challenge. Currently, diagnosis relies on clinical and laboratory findings as well as skin histology. The Cutaneous Lupus Area and Severity Index™ (CLASI™) is a validated measure of disease activity and damage. CLE pathogenesis is multifactorial and includes genetic contributions as well as effects of ultraviolet (UV) light. Immune dysregulation and aberrant cell signaling pathways through cytokine cascades are also implicated. Patient education and avoidance of triggers are key to disease prevention. Antimalarials and topical steroids continue to be the standard of care; however, immunosuppressants, thalidomide analogs and monoclonal antibodies are possible systemic therapies for the treatment of recalcitrant disease. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 33% |
| Germany | 1 | 11% |
| Colombia | 1 | 11% |
| Spain | 1 | 11% |
| Italy | 1 | 11% |
| Unknown | 2 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 56% |
| Scientists | 2 | 22% |
| Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 167 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 21 | 13% |
| Student > Bachelor | 18 | 11% |
| Student > Doctoral Student | 17 | 10% |
| Student > Master | 16 | 10% |
| Other | 15 | 9% |
| Other | 34 | 20% |
| Unknown | 46 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 79 | 47% |
| Immunology and Microbiology | 9 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Biochemistry, Genetics and Molecular Biology | 5 | 3% |
| Nursing and Health Professions | 4 | 2% |
| Other | 14 | 8% |
| Unknown | 51 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2022.
All research outputs
#3,151,240
of 25,450,869 outputs
Outputs from American Journal of Clinical Dermatology
#238
of 1,067 outputs
Outputs of similar age
#53,356
of 410,403 outputs
Outputs of similar age from American Journal of Clinical Dermatology
#5
of 16 outputs
Altmetric has tracked 25,450,869 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,067 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 410,403 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.