Title |
Treatment of Edema Associated With Intracerebral Hemorrhage
|
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Published in |
Current Treatment Options in Neurology, February 2016
|
DOI | 10.1007/s11940-015-0392-z |
Pubmed ID | |
Authors |
Audrey Leasure, W. Taylor Kimberly, Lauren H. Sansing, Kristopher T. Kahle, Golo Kronenberg, Hagen Kunte, J. Marc Simard, Kevin N. Sheth |
Abstract |
Cerebral edema (i.e., "brain swelling") is a common complication following intracerebral hemorrhage (ICH) and is associated with worse clinical outcomes. Perihematomal edema (PHE) accumulates during the first 72 h after hemorrhage, and during this period, patients are at risk of clinical deterioration due to the resulting tissue shifts and brain herniation. First-line medical therapies for patients symptomatic of PHE include osmotic agents, such as mannitol in low- or high-dose bolus form, or boluses of hypertonic saline (HTS) at varied concentrations with or without subsequent continuous infusion. Decompressive craniectomy may be required for symptomatic edema refractory to osmotherapy. Other strategies that reduce PHE such as hypothermia and minimally invasive surgery have shown promise in pilot studies and are currently being evaluated in larger clinical trials. Ongoing basic, translational, and clinical research seek to better elucidate the pathophysiology of PHE to identify novel strategies to prevent edema formation as a next major advance in the treatment of ICH. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 6 | 16% |
Researcher | 5 | 14% |
Student > Bachelor | 5 | 14% |
Other | 3 | 8% |
Professor > Associate Professor | 3 | 8% |
Other | 6 | 16% |
Unknown | 9 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 49% |
Neuroscience | 4 | 11% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Agricultural and Biological Sciences | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 2 | 5% |
Unknown | 10 | 27% |