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Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall.

Overview of attention for article published in American Journal of Neuroradiology, February 2019
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Title
Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall.
Published in
American Journal of Neuroradiology, February 2019
DOI 10.3174/ajnr.a5970
Pubmed ID
Authors

J R Cebral, F Detmer, B J Chung, J Choque-Velasquez, B Rezai, H Lehto, R Tulamo, J Hernesniemi, M Niemela, A Yu, R Williamson, K Aziz, S Shakur, S Amin-Hanjani, F Charbel, Y Tobe, A Robertson, J Frösen

Abstract

Aneurysm hemodynamics has been associated with wall histology and inflammation. We investigated associations between local hemodynamics and focal wall changes visible intraoperatively. Computational fluid dynamics models were constructed from 3D images of 65 aneurysms treated surgically. Aneurysm regions with different visual appearances were identified in intraoperative videos: 1) "atherosclerotic" (yellow), 2) "hyperplastic" (white), 3) "thin" (red), 4) rupture site, and 5) "normal" (similar to parent artery), They were marked on 3D reconstructions. Regional hemodynamics was characterized by the following: wall shear stress, oscillatory shear index, relative residence time, wall shear stress gradient and divergence, gradient oscillatory number, and dynamic pressure; these were compared using the Mann-Whitney test. Hyperplastic regions had lower average wall shear stress (P = .005) and pressure (P = .009) than normal regions. Flow conditions in atherosclerotic and hyperplastic regions were similar but had higher average relative residence time (P = .03) and oscillatory shear index (P = .04) than thin regions. Hyperplastic regions also had a higher average gradient oscillatory number (P = .002) than thin regions. Thin regions had lower average relative residence time (P < .001), oscillatory shear index (P = .006), and gradient oscillatory number (P < .001) than normal regions, and higher average wall shear stress (P = .006) and pressure (P = .009) than hyperplastic regions. Thin regions tended to be aligned with the flow stream, while atherosclerotic and hyperplastic regions tended to be aligned with recirculation zones. Local hemodynamics is associated with visible focal wall changes. Slow swirling flow with low and oscillatory wall shear stress was associated with atherosclerotic and hyperplastic changes. High flow conditions prevalent in regions near the flow impingement site characterized by higher and less oscillatory wall shear stress were associated with local "thinning" of the wall.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 15%
Researcher 9 14%
Student > Ph. D. Student 9 14%
Student > Bachelor 5 8%
Professor 4 6%
Other 10 15%
Unknown 19 29%
Readers by discipline Count As %
Engineering 20 30%
Medicine and Dentistry 12 18%
Neuroscience 3 5%
Biochemistry, Genetics and Molecular Biology 2 3%
Agricultural and Biological Sciences 2 3%
Other 5 8%
Unknown 22 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2019.
All research outputs
#15,175,718
of 25,385,509 outputs
Outputs from American Journal of Neuroradiology
#3,184
of 5,257 outputs
Outputs of similar age
#234,596
of 446,281 outputs
Outputs of similar age from American Journal of Neuroradiology
#65
of 88 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,257 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,281 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.