Title |
Molecular background of oligodendroglioma: 1p/19q, IDH, TERT, CIC and FUBP1
|
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Published in |
CNS Oncology, November 2015
|
DOI | 10.2217/cns.15.32 |
Pubmed ID | |
Authors |
Daniel P Cahill, David N Louis, John Gregory Cairncross |
Abstract |
Oligodendroglioma is the quintessential molecularly-defined brain tumor. The characteristic whole-arm loss of the long arm of chromosome 1 and the short arm of chromosome 19 (1p/19q-codeletion) within the genome of these tumors facilitated the reproducible molecular identification of this subcategory of gliomas. More recently, recurrent molecular genetic alterations have been identified to occur concurrently with 1p/19q-codeletion, and definitively identify these tumors, including mutations in IDH1/2, CIC, FUBP1, and the TERT promoter, as well as the absence of ATRX and TP53 alterations. These findings provide a foundation for the consistent diagnosis of this tumor type, upon which a generation of clinical investigators have assembled a strong evidence base for the effective treatment of this disease with radiation and chemotherapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 40% |
Mexico | 1 | 20% |
France | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 10 | 21% |
Student > Ph. D. Student | 6 | 13% |
Student > Doctoral Student | 5 | 11% |
Student > Master | 3 | 6% |
Student > Postgraduate | 3 | 6% |
Other | 7 | 15% |
Unknown | 13 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 30% |
Biochemistry, Genetics and Molecular Biology | 11 | 23% |
Agricultural and Biological Sciences | 2 | 4% |
Neuroscience | 2 | 4% |
Immunology and Microbiology | 1 | 2% |
Other | 1 | 2% |
Unknown | 16 | 34% |