Title |
Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study
|
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Published in |
Lancet Neurology, January 2012
|
DOI | 10.1016/s1474-4422(11)70305-2 |
Pubmed ID | |
Authors |
Peter Connick, Madhan Kolappan, Charles Crawley, Daniel J Webber, Rickie Patani, Andrew W Michell, Ming-Qing Du, Shi-Lu Luan, Daniel R Altmann, Alan J Thompson, Alastair Compston, Michael A Scott, David H Miller, Siddharthan Chandran |
Abstract |
More than half of patients with multiple sclerosis have progressive disease characterised by accumulating disability. The absence of treatments for progressive multiple sclerosis represents a major unmet clinical need. On the basis of evidence that mesenchymal stem cells have a beneficial effect in acute and chronic animal models of multiple sclerosis, we aimed to assess the safety and efficacy of these cells as a potential neuroprotective treatment for secondary progressive multiple sclerosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 34% |
Saudi Arabia | 5 | 17% |
Comoros | 1 | 3% |
Panama | 1 | 3% |
United Kingdom | 1 | 3% |
Spain | 1 | 3% |
Italy | 1 | 3% |
Unknown | 9 | 31% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 26 | 90% |
Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Scientists | 1 | 3% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | <1% |
Germany | 2 | <1% |
Brazil | 2 | <1% |
Turkey | 1 | <1% |
Netherlands | 1 | <1% |
Portugal | 1 | <1% |
Sweden | 1 | <1% |
South Africa | 1 | <1% |
Korea, Republic of | 1 | <1% |
Other | 4 | <1% |
Unknown | 454 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 78 | 17% |
Researcher | 64 | 14% |
Student > Bachelor | 59 | 13% |
Student > Master | 58 | 12% |
Student > Doctoral Student | 24 | 5% |
Other | 95 | 20% |
Unknown | 94 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 131 | 28% |
Agricultural and Biological Sciences | 66 | 14% |
Biochemistry, Genetics and Molecular Biology | 53 | 11% |
Neuroscience | 28 | 6% |
Engineering | 23 | 5% |
Other | 51 | 11% |
Unknown | 120 | 25% |