| Title |
Activation of transcriptional activity of HSE by a novel mouse zinc finger protein ZNFD specifically expressed in testis
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, January 2012
|
| DOI | 10.1007/s11010-011-1193-7 |
| Pubmed ID | |
| Authors |
Fengqin Xu, Weiping Wang, Chen Lei, Qingmei Liu, Hao Qiu, Vinaydhar Muraleedharan, Bin Zhou, Hongxia Cheng, Zhongkai Huang, Weian Xu, Bichun Li, Minghua Wang |
| Abstract |
Zinc finger proteins (ZFPs) that contain multiple cysteine and/or histidine residues perform important roles in various cellular functions, including transcriptional regulation, cell proliferation, differentiation, and apoptosis. The Cys-Cys-His-His (C(2)H(2)) type of ZFPs are the well-defined members of this super family and are the largest and most complex proteins in eukaryotic genomes. In this study, we identified a novel C(2)H(2) type of zinc finger gene ZNFD from mice which has a 1,002 bp open reading frame and encodes a protein with 333 amino acid residues. The predicted 37.4 kDa protein contains a C(2)H(2) zinc finger domain. ZNFD gene is located on chromosome 18qD1. RT-PCR analysis revealed that the ZNFD gene was specifically expressed in mouse testis but not in other tissues. Subcellular localization analysis demonstrated that ZNFD was localized in the nucleus. Reporter gene assays showed that overexpression of ZNFD in the COS7 cells activates the transcriptional activities of heat shock element (HSE). Overall, these results suggest that ZNFD is a member of the zinc finger transcription factor family and it participates in the transcriptional regulation of HSE. Many heat shock proteins regulated by HSE are involved in testicular development. Therefore, our results suggest that ZNFD may probably participate in the development of mouse testis and function as a transcription activator in HSE-mediated gene expression and signaling pathways. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 2 | 20% |
| Student > Ph. D. Student | 2 | 20% |
| Lecturer > Senior Lecturer | 1 | 10% |
| Other | 1 | 10% |
| Student > Master | 1 | 10% |
| Other | 2 | 20% |
| Unknown | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 30% |
| Veterinary Science and Veterinary Medicine | 1 | 10% |
| Chemical Engineering | 1 | 10% |
| Nursing and Health Professions | 1 | 10% |
| Agricultural and Biological Sciences | 1 | 10% |
| Other | 2 | 20% |
| Unknown | 1 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2012.
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#18,303,566
of 22,661,413 outputs
Outputs from Molecular and Cellular Biochemistry
#1,552
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#194,726
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Outputs of similar age from Molecular and Cellular Biochemistry
#18
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