| Title |
Glucocorticoid-induced osteonecrosis
|
|---|---|
| Published in |
Endocrine, December 2011
|
| DOI | 10.1007/s12020-011-9580-0 |
| Pubmed ID | |
| Authors |
Robert S. Weinstein |
| Abstract |
Awareness of the need for prevention of glucocorticoid-induced fractures is growing, but glucocorticoid administration is often overlooked as the most common cause of nontraumatic osteonecrosis. Glucocorticoid-induced osteonecrosis develops in 9-40% of patients receiving long-term therapy although it may also occur with short-term exposure to high doses, after intra-articular injection, and without glucocorticoid-induced osteoporosis. The name, osteonecrosis, is misleading because the primary histopathological lesion is osteocyte apoptosis. Apoptotic osteocytes persist because they are anatomically unavailable for phagocytosis and, with glucocorticoid excess, decreased bone remodeling retards their replacement. Glucocorticoid-induced osteocyte apoptosis, a cumulative and unrepairable defect, uniquely disrupts the mechanosensory function of the osteocyte-lacunar-canalicular system and thus starts the inexorable sequence of events leading to collapse of the femoral head. Current evidence indicates that bisphosphonates may rapidly reduce pain, increase ambulation, and delay joint collapse in patients with osteonecrosis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 190 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 13% |
| Researcher | 21 | 11% |
| Student > Bachelor | 16 | 8% |
| Student > Postgraduate | 14 | 7% |
| Student > Master | 14 | 7% |
| Other | 43 | 23% |
| Unknown | 57 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 75 | 39% |
| Agricultural and Biological Sciences | 21 | 11% |
| Biochemistry, Genetics and Molecular Biology | 9 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Nursing and Health Professions | 3 | 2% |
| Other | 13 | 7% |
| Unknown | 65 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2023.
All research outputs
#6,443,851
of 23,283,373 outputs
Outputs from Endocrine
#379
of 1,723 outputs
Outputs of similar age
#57,086
of 245,102 outputs
Outputs of similar age from Endocrine
#2
of 16 outputs
Altmetric has tracked 23,283,373 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,723 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,102 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.