| Title |
Multidimensional assessment of neuroendocrine and psychopathological profiles in maltreated youth
|
|---|---|
| Published in |
Journal of Neural Transmission, February 2016
|
| DOI | 10.1007/s00702-016-1509-6 |
| Pubmed ID | |
| Authors |
Vanessa B. Puetz, Jana Zweerings, Brigitte Dahmen, Caroline Ruf, Wolfgang Scharke, Beate Herpertz-Dahlmann, Kerstin Konrad |
| Abstract |
It has been debated whether children who have experienced early life stress (ELS), such as early caregiver separation show elevated risk for stress-related psychiatric disorders and a multi-symptom psychopathological profile that is not fully reflected in categorical assessments. In this study, we investigated dimensional measures of stress-related psychopathology in children in permanent out-of-home care, taking into account potential neuroendocrine interactions. In the current study, 25 children who had been placed in permanent out-of-home care before age 3 (years) and 26 controls (aged 10.6 ± 1.75 years) were investigated with categorical (DSM-IV) and dimensional assessments (CBCL) of psychopathology and diurnal salivary cortisol levels were assessed. Semi-structured interviews (K-DIPS) revealed no significant group differences in full-scale psychiatric diagnoses, whereas dimensional assessment (CBCL) revealed significant group differences in externalizing and total problem behaviours within the clinical range for children with ELS. Only children with ELS showed a combined symptom profile of clinical-range internalizing and externalizing problems. Lower morning cortisol values and subsequent flatter decline was found in subjects with ELS children compared to controls, showing group differences in diurnal cortisol secretion. Lower morning cortisol values were associated with more problem behaviour in the ELS group. Results show that ELS children exhibited increased psychopathological symptom severity and complexity associated with lower morning cortisol levels, which was not fully reflected in categorical assessments. This highlights the importance of incorporating dimensional assessments and neurobiological factors into psychopathological evaluations of children in out-of-home care in order to facilitate early identification of children at high risk for stress-related disorders. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| Unknown | 123 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 18% |
| Student > Ph. D. Student | 18 | 15% |
| Student > Bachelor | 17 | 14% |
| Researcher | 11 | 9% |
| Student > Doctoral Student | 7 | 6% |
| Other | 16 | 13% |
| Unknown | 33 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 46 | 37% |
| Medicine and Dentistry | 11 | 9% |
| Social Sciences | 8 | 6% |
| Neuroscience | 6 | 5% |
| Nursing and Health Professions | 4 | 3% |
| Other | 10 | 8% |
| Unknown | 39 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2016.
All research outputs
#17,785,991
of 22,846,662 outputs
Outputs from Journal of Neural Transmission
#1,356
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Outputs of similar age
#273,779
of 400,824 outputs
Outputs of similar age from Journal of Neural Transmission
#23
of 28 outputs
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