| Title |
Epigenetic modifications in cardiovascular disease
|
|---|---|
| Published in |
Basic Research in Cardiology, January 2012
|
| DOI | 10.1007/s00395-012-0245-9 |
| Pubmed ID | |
| Authors |
Johan M. Lorenzen, Filippo Martino, Thomas Thum |
| Abstract |
Epigenetics represents a phenomenon of altered heritable phenotypic expression of genetic information occurring without changes in DNA sequence. Epigenetic modifications control embryonic development, differentiation and stem cell (re)programming. These modifications can be affected by exogenous stimuli (e.g., diabetic milieu, smoking) and oftentimes culminate in disease initiation. DNA methylation has been studied extensively and represents a well-understood epigenetic mechanism. During this process cytosine residues preceding a guanosine in the DNA sequence are methylated. CpG-islands are short-interspersed DNA sequences with clusters of CG sequences. The abnormal methylation of CpG islands in the promoter region of genes leads to a silencing of genetic information and finally to alteration of biological function. Emerging data suggest that these epigenetic modifications also impact on the development of cardiovascular disease. Histone modifications lead to the modulation of the expression of genetic information through modification of DNA accessibility. In addition, RNA-based mechanisms (e.g., microRNAs and long non-coding RNAs) influence the development of disease. We here outline the recent work pertaining to epigenetic changes in a cardiovascular disease setting. |
Mendeley readers
The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| Italy | 1 | <1% |
| India | 1 | <1% |
| Netherlands | 1 | <1% |
| Czechia | 1 | <1% |
| Belgium | 1 | <1% |
| China | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 145 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 23% |
| Researcher | 29 | 19% |
| Student > Master | 21 | 14% |
| Student > Bachelor | 13 | 8% |
| Other | 9 | 6% |
| Other | 27 | 17% |
| Unknown | 21 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 32% |
| Medicine and Dentistry | 27 | 17% |
| Biochemistry, Genetics and Molecular Biology | 26 | 17% |
| Engineering | 4 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 15 | 10% |
| Unknown | 30 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2016.
All research outputs
#7,412,246
of 22,661,413 outputs
Outputs from Basic Research in Cardiology
#180
of 643 outputs
Outputs of similar age
#70,581
of 243,373 outputs
Outputs of similar age from Basic Research in Cardiology
#2
of 8 outputs
Altmetric has tracked 22,661,413 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 643 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,373 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.