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Mendeley readers
| Title |
A novel impinging aerosols method for production of propranolol hydrochloride-loaded alginate gel microspheres for oral delivery
|
|---|---|
| Published in |
Journal of Microencapsulation, December 2011
|
| DOI | 10.3109/02652048.2011.629746 |
| Pubmed ID | |
| Authors |
Dewi Melani Hariyadi, Thor Bostrom, Bhesh Bhandari, Allan G. A. Coombes |
| Abstract |
Propranolol hydrochloride was directly encapsulated in alginate gel microspheres (40-50 µm in diameter) using a novel method involving impinging aerosols of CaCl(2) cross-linking solution and sodium alginate solution containing the drug. Microspheres formulated using 0.1 M CaCl(2) exhibited the highest drug loading (14%, w/w of dry microspheres) with 66.5% encapsulation efficiency. Less than 4% and 35% propranolol release occurred from hydrated and dried microspheres, respectively, in 2 h in simulated gastric fluid (SGF). The majority of the drug load (90%) was released in 5 and 7 h from hydrated and dried microspheres, respectively, in simulated intestinal fluid (SIF). Prior incubation of hydrated microspheres (cross-linked using 0.5 M CaCl(2)) in SGF prolonged the time of release in SIF to 10 h, which has implications for the design of protocols and correlation with in vivo release behaviour. Restricted propranolol release in SGF and complete extraction in SIF demonstrate the potential of alginate gel microspheres for oral delivery of pharmaceuticals. |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 28% |
| Student > Doctoral Student | 3 | 17% |
| Student > Postgraduate | 2 | 11% |
| Professor | 1 | 6% |
| Lecturer > Senior Lecturer | 1 | 6% |
| Other | 2 | 11% |
| Unknown | 4 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 28% |
| Agricultural and Biological Sciences | 4 | 22% |
| Veterinary Science and Veterinary Medicine | 1 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Medicine and Dentistry | 1 | 6% |
| Other | 2 | 11% |
| Unknown | 4 | 22% |