| Title |
Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?
|
|---|---|
| Published in |
Journal of Assisted Reproduction and Genetics, July 2011
|
| DOI | 10.1007/s10815-011-9608-7 |
| Pubmed ID | |
| Authors |
Kim Dao Ly, Ashok Agarwal, Zsolt Peter Nagy |
| Abstract |
Despite an ongoing debate over its efficacy, preimplantation genetic screening (PGS) is increasingly being used to detect numerical chromosomal abnormalities in embryos to improve implantation rates after IVF. The main indications for the use of PGS in IVF treatments include advanced maternal age, repeated implantation failure, and recurrent pregnancy loss. The success of PGS is highly dependent on technical competence, embryo culture quality, and the presence of mosaicism in preimplantation embryos. Today, cleavage stage biopsy is the most commonly used method for screening preimplantation embryos for aneuploidy. However, blastocyst biopsy is rapidly becoming the more preferred method due to a decreased likelihood of mosaicism and an increase in the amount of DNA available for testing. Instead of using 9 to 12 chromosome FISH, a 24 chromosome detection by aCGH or SNP microarray will be used. Thus, it is advised that before attempting to perform PGS and expecting any benefit, extended embryo culture towards day 5/6 should be established and proven and the clinical staff should demonstrate competence with routine competency assessments. A properly designed randomized control trial is needed to test the potential benefits of these new developments. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 96 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 21 | 21% |
| Researcher | 17 | 17% |
| Student > Master | 14 | 14% |
| Student > Doctoral Student | 6 | 6% |
| Student > Ph. D. Student | 6 | 6% |
| Other | 20 | 20% |
| Unknown | 14 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 34% |
| Biochemistry, Genetics and Molecular Biology | 20 | 20% |
| Agricultural and Biological Sciences | 19 | 19% |
| Nursing and Health Professions | 3 | 3% |
| Computer Science | 1 | 1% |
| Other | 5 | 5% |
| Unknown | 17 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2012.
All research outputs
#19,611,252
of 24,119,703 outputs
Outputs from Journal of Assisted Reproduction and Genetics
#1,199
of 1,697 outputs
Outputs of similar age
#100,277
of 119,251 outputs
Outputs of similar age from Journal of Assisted Reproduction and Genetics
#10
of 11 outputs
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