| Title |
Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
|
|---|---|
| Published in |
Journal of Molecular Medicine, January 2012
|
| DOI | 10.1007/s00109-011-0856-x |
| Pubmed ID | |
| Authors |
Gabriella Aviello, Barbara Romano, Francesca Borrelli, Raffaele Capasso, Laura Gallo, Fabiana Piscitelli, Vincenzo Di Marzo, Angelo A. Izzo |
| Abstract |
Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant and intestinal antinflammatory) and mechanisms (inhibition of endocannabinoid enzymatic degradation) potentially beneficial for colon carcinogenesis. Thus, we investigated its possible chemopreventive effect in the model of colon cancer induced by azoxymethane (AOM) in mice. AOM treatment was associated with aberrant crypt foci (ACF, preneoplastic lesions), polyps, and tumour formation, up-regulation of phospho-Akt, iNOS and COX-2 and down-regulation of caspase-3. Cannabidiol-reduced ACF, polyps and tumours and counteracted AOM-induced phospho-Akt and caspase-3 changes. In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARγ-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms. |
X Demographics
The data shown below were collected from the profiles of 81 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 27 | 33% |
| Indonesia | 8 | 10% |
| Canada | 2 | 2% |
| Austria | 1 | 1% |
| Netherlands | 1 | 1% |
| United Kingdom | 1 | 1% |
| Portugal | 1 | 1% |
| France | 1 | 1% |
| Jamaica | 1 | 1% |
| Other | 2 | 2% |
| Unknown | 36 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 72 | 89% |
| Practitioners (doctors, other healthcare professionals) | 6 | 7% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
| Scientists | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 1% |
| United States | 3 | 1% |
| Croatia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 232 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 14% |
| Student > Master | 33 | 14% |
| Researcher | 32 | 13% |
| Student > Bachelor | 32 | 13% |
| Student > Doctoral Student | 17 | 7% |
| Other | 36 | 15% |
| Unknown | 57 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 16% |
| Medicine and Dentistry | 34 | 14% |
| Biochemistry, Genetics and Molecular Biology | 31 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 25 | 10% |
| Chemistry | 12 | 5% |
| Other | 34 | 14% |
| Unknown | 65 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 255. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2024.
All research outputs
#142,548
of 25,216,325 outputs
Outputs from Journal of Molecular Medicine
#4
of 1,637 outputs
Outputs of similar age
#618
of 254,503 outputs
Outputs of similar age from Journal of Molecular Medicine
#1
of 16 outputs
Altmetric has tracked 25,216,325 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,637 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 254,503 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.