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The tolerability of a combined hepatitis A and typhoid vaccine in children aged 2–16 years: an observational study †

Overview of attention for article published in Journal of Travel Medicine, February 2016
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Title
The tolerability of a combined hepatitis A and typhoid vaccine in children aged 2–16 years: an observational study †
Published in
Journal of Travel Medicine, February 2016
DOI 10.1093/jtm/tav023
Pubmed ID
Authors

Colleen L. Lau, Catherine L. Streeton, Michael C. David, Peter D. Sly, Deborah J. Mills

Abstract

Combined hepatitis A and typhoid vaccines have been widely used globally and proven to be safe, well tolerated and efficacious in adults. The combined hepatitis A and typhoid vaccine (Vivaxim) available in Australia is licenced for use from age 16 years but the monovalent components are approved for use from age 2 years. Advantages of a single injection have led to widespread 'off-label' use of Vivaxim in children. This study aimed to investigate the tolerability of Vivaxim in children aged 2-16 years. A prospective observational study was conducted at Travel Medicine Alliance clinics across Australia. Children who required vaccination for both hepatitis A and typhoid were offered the option of receiving Vivaxim. Parents were contacted 3 days post-vaccination and asked to respond to a questionnaire on adverse events following immunization (AEFIs). Reactions to Vivaxim were compared with reported reactions to the monovalent vaccines. Our study included 425 children who received Vivaxim, including 189 (44.5%) who received other vaccines on the same day. No serious AEFIs were reported, and 26.8% did not experience any side effects. In children who did not receive other vaccines in the same arm as Vivaxim (n = 325), most common local reactions were sore arm (70.5%), redness (16.0%) and swelling (11.1%). Reports of local AEFIs in our subjects was significantly more common than those reported for the individual monovalent vaccines. In children who did not receive other vaccines on the same day (n = 236), the most common systemic reactions were tiredness/lethargy/malaise (5.9%), headache (4.2%), fever (3.4%) and sore muscles and joints (3.4%). Fever was more common in children aged <6 years. Less than 5% of children reported missing school, sport or other regular activities. Vivaxim was well tolerated in children aged 2-16 years. Parents should be advised about AEFIs to Vivaxim so that they can make informed decisions about vaccination options.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 20%
Student > Postgraduate 5 14%
Student > Ph. D. Student 4 11%
Other 3 9%
Student > Doctoral Student 2 6%
Other 6 17%
Unknown 8 23%
Readers by discipline Count As %
Medicine and Dentistry 15 43%
Nursing and Health Professions 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Immunology and Microbiology 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 1 3%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2016.
All research outputs
#14,837,567
of 22,849,304 outputs
Outputs from Journal of Travel Medicine
#829
of 1,210 outputs
Outputs of similar age
#225,761
of 403,162 outputs
Outputs of similar age from Journal of Travel Medicine
#17
of 30 outputs
Altmetric has tracked 22,849,304 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,210 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.5. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 403,162 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.