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Mendeley readers
Attention Score in Context
| Title |
Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, December 2001
|
| DOI | 10.1073/pnas.012610299 |
| Pubmed ID | |
| Authors |
Yaacov Barak, Debbie Liao, Weimin He, Estelita S. Ong, Michael C. Nelson, Jerrold M. Olefsky, Richard Boland, Ronald M. Evans |
| Abstract |
Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor delta (PPARdelta) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving PPARdelta(-/-) mice exhibit a striking reduction in adiposity relative to wild-type levels. This effect is not reproduced in mice harboring an adipose tissue-specific deletion of PPARdelta, and thus likely reflects peripheral PPARdelta functions in systemic lipid metabolism. Finally, we observe that PPARdelta is dispensable for polyp formation in the intestine and colon of APC(min) mice, inconsistent with its recently proposed role in the establishment of colorectal tumors. Together, these observations reveal specific roles for PPARdelta in embryo development and adipocyte physiology, but not cancer. |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 2 | 2% |
| Brazil | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 123 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 19% |
| Researcher | 25 | 19% |
| Professor > Associate Professor | 13 | 10% |
| Student > Master | 10 | 8% |
| Student > Bachelor | 9 | 7% |
| Other | 31 | 24% |
| Unknown | 18 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 40% |
| Medicine and Dentistry | 22 | 17% |
| Biochemistry, Genetics and Molecular Biology | 17 | 13% |
| Immunology and Microbiology | 4 | 3% |
| Psychology | 2 | 2% |
| Other | 8 | 6% |
| Unknown | 26 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2019.
All research outputs
#5,225,908
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#46,893
of 101,438 outputs
Outputs of similar age
#14,375
of 128,968 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#153
of 441 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 128,968 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 441 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.