Title |
Regulation of cardiomyocyte autophagy by calcium
|
---|---|
Published in |
American Journal of Physiology: Endocrinology & Metabolism, February 2016
|
DOI | 10.1152/ajpendo.00374.2015 |
Pubmed ID | |
Authors |
Soni Shaikh, Rodrigo Troncoso, Alfredo Criollo, Roberto Bravo-Sagua, Lorena García, Eugenia Morselli, Mariana Cifuentes, Andrew F G Quest, Joseph A Hill, Sergio Lavandero |
Abstract |
Shaikh S, Troncoso R, Criollo A, Bravo-Sagua R, Morselli E, García L, Cifuentes M, Quest A.F.G, Hill J.A, Lavandero S. Regulation of cardiomyocyte autophagy by calcium. Am J Physiol Endocrinol Metab Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, inter-organelle communication, and other key signaling events that govern cardiomyocyte autophagy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
China | 1 | 3% |
Unknown | 37 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 21% |
Researcher | 7 | 18% |
Student > Doctoral Student | 4 | 11% |
Student > Bachelor | 4 | 11% |
Student > Master | 4 | 11% |
Other | 9 | 24% |
Unknown | 2 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 29% |
Agricultural and Biological Sciences | 11 | 29% |
Medicine and Dentistry | 6 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 3 | 8% |
Unknown | 5 | 13% |