Title |
Maintenance Treatment by Erlotinib and Toxic Cardiomyopathy: A Case Report
|
---|---|
Published in |
Oncology, February 2016
|
DOI | 10.1159/000444186 |
Pubmed ID | |
Authors |
François Pinquié, Gonzagues de Chabot, Thierry Urban, José Hureaux |
Abstract |
Erlotinib maintenance treatment improves progression-free survival compared with observation after first-line chemotherapy in unselected advanced non-small cell lung cancer (NSCLC). Very few cardiac adverse effects have been observed in phase III studies on tyrosine kinase inhibitors (TKI). We report the case of a 71-year-old woman with metastatic NSCLC treated with cisplatin/pemetrexed and then erlotinib maintenance therapy. After 26 months of TKI therapy, she developed dilated cardiomyopathy. Despite symptomatic treatment, left ventricular ejection fraction decreased to 25%. Ischemic heart disease was excluded by coronary angiography and cardiac magnetic resonance imaging, and no other cause was found. Erlotinib was stopped, and cardiac resynchronization therapy by pacemaker was initiated. This case report highlights the possible cardiotoxic effects of long-term erlotinib and suggests the need for close clinical and echocardiographic follow-up of patients receiving long-term TKI therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 6 | 21% |
Student > Doctoral Student | 5 | 17% |
Student > Bachelor | 3 | 10% |
Researcher | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Other | 4 | 14% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 55% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 14% |
Nursing and Health Professions | 2 | 7% |
Computer Science | 1 | 3% |
Unknown | 6 | 21% |