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Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma

Overview of attention for article published in Journal of Comparative Pathology, February 2016
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Title
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma
Published in
Journal of Comparative Pathology, February 2016
DOI 10.1016/j.jcpa.2016.01.002
Pubmed ID
Authors

G. Hood, R. Laufer-Amorim, C.E. Fonseca-Alves, C. Palmieri

Abstract

Ephrin A3 (EphA3), a member of the ephrin receptor tyrosine kinase family, is involved in a variety of functions in normal cells, especially during embryonic development, and alterations in its expression profile have been observed in several human cancers. However, there are no reports of the expression of EphA3 in normal, hyperplastic or neoplastic canine prostate tissue or in other types of canine tumours. Six normal, 15 hyperplastic and 21 neoplastic canine prostates were examined immunohistochemically with a polyclonal antibody specific for human EphA3. The percentage of positive cells in all prostatic carcinomas was increased, with a mean of 89.28 ± 5.18% compared with normal (9.17 ± 6.72%) and hyperplastic prostates (20.00 ± 8.28%). EphA3 expression was not correlated with the histological subtypes of prostate cancer or with the Gleason score. The increase in EphA3 expression in canine prostatic carcinomas suggests the involvement of this receptor in prostatic carcinogenesis and its potential use as a target for new therapeutic strategies.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 9 21%
Student > Master 6 14%
Researcher 5 12%
Student > Doctoral Student 5 12%
Student > Ph. D. Student 4 10%
Other 11 26%
Unknown 2 5%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 23 55%
Medicine and Dentistry 6 14%
Agricultural and Biological Sciences 2 5%
Biochemistry, Genetics and Molecular Biology 1 2%
Computer Science 1 2%
Other 3 7%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2016.
All research outputs
#19,942,887
of 25,371,288 outputs
Outputs from Journal of Comparative Pathology
#816
of 1,355 outputs
Outputs of similar age
#215,523
of 311,609 outputs
Outputs of similar age from Journal of Comparative Pathology
#15
of 27 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,355 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,609 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.