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Intercellular Connections Related to Cell–Cell Crosstalk Specifically Recognized by an Aptamer

Overview of attention for article published in Angewandte Chemie. International Edition, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
5 X users
facebook
1 Facebook page
f1000
1 research highlight platform

Citations

dimensions_citation
36 Dimensions

Readers on

mendeley
42 Mendeley
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Title
Intercellular Connections Related to Cell–Cell Crosstalk Specifically Recognized by an Aptamer
Published in
Angewandte Chemie. International Edition, February 2016
DOI 10.1002/anie.201510786
Pubmed ID
Authors

Nan Zhang, Tao Bing, Luyao Shen, Rusheng Song, Linlin Wang, Xiangjun Liu, Meirong Liu, Juan Li, Weihong Tan, Dihua Shangguan

Abstract

Intercellular connections are an important pathway for cell-cell crosstalk. However, their formation mechanism and functions are far from being understood. The lack of molecular probes hampers the research in this area. Herein, we report a kind of intercellular connection that is specifically recognized by aptamer M17A2 generated by cell-SELEX against MCF-7R cells. These connections have different morphologies, but have the same skeleton composed of F-actin. The long filamentous connections were identified to be tunneling nanotubes (TNTs), a recently discovered cell-cell communication route. These connections could be built not only between MCF-7R cells, but also from MCF-7R to other cells after co-culture. Proteins could be transported between cells through these connections, suggesting their cell communication function. Aptamer M17A2 shows the potential to act as a new probe for investigating this kind of intercellular connection, as well as for studying cell-cell communication.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 19%
Student > Ph. D. Student 6 14%
Student > Master 5 12%
Student > Doctoral Student 3 7%
Other 3 7%
Other 8 19%
Unknown 9 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 26%
Chemistry 8 19%
Agricultural and Biological Sciences 5 12%
Medicine and Dentistry 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 2 5%
Unknown 11 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2019.
All research outputs
#2,059,655
of 25,374,647 outputs
Outputs from Angewandte Chemie. International Edition
#4,279
of 49,993 outputs
Outputs of similar age
#32,250
of 311,954 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#76
of 715 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,993 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 715 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.