Title |
Intercellular Connections Related to Cell–Cell Crosstalk Specifically Recognized by an Aptamer
|
---|---|
Published in |
Angewandte Chemie. International Edition, February 2016
|
DOI | 10.1002/anie.201510786 |
Pubmed ID | |
Authors |
Nan Zhang, Tao Bing, Luyao Shen, Rusheng Song, Linlin Wang, Xiangjun Liu, Meirong Liu, Juan Li, Weihong Tan, Dihua Shangguan |
Abstract |
Intercellular connections are an important pathway for cell-cell crosstalk. However, their formation mechanism and functions are far from being understood. The lack of molecular probes hampers the research in this area. Herein, we report a kind of intercellular connection that is specifically recognized by aptamer M17A2 generated by cell-SELEX against MCF-7R cells. These connections have different morphologies, but have the same skeleton composed of F-actin. The long filamentous connections were identified to be tunneling nanotubes (TNTs), a recently discovered cell-cell communication route. These connections could be built not only between MCF-7R cells, but also from MCF-7R to other cells after co-culture. Proteins could be transported between cells through these connections, suggesting their cell communication function. Aptamer M17A2 shows the potential to act as a new probe for investigating this kind of intercellular connection, as well as for studying cell-cell communication. |
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