Title |
Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial
|
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Published in |
Current Medical Research & Opinion, January 2012
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DOI | 10.1185/03007995.2011.648758 |
Pubmed ID | |
Authors |
Cyrus Cooper, Jean-Yves Reginster, Roland Chapurlat, Claus Christiansen, Harry Genant, Nicholas Bellamy, William Bensen, Federico Navarro, Janusz Badurski, Evgeny Nasonov, Xavier Chevalier, Philip N. Sambrook |
Abstract |
The osteoporosis drug strontium ranelate dissociates bone remodelling processes. It also inhibits subchondral bone resorption and stimulates cartilage matrix formation in vitro. Exploratory studies in the osteoporosis trials report that strontium ranelate reduces biomarkers of cartilage degradation, and attenuates the progression and clinical symptoms of spinal osteoarthritis, suggesting symptom- and structure-modifying activity in osteoarthritis. We describe the rationale and design of a randomised trial evaluating the efficacy and safety of strontium ranelate in knee osteoarthritis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mauritius | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 55 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 14% |
Student > Master | 7 | 12% |
Student > Bachelor | 6 | 11% |
Student > Ph. D. Student | 5 | 9% |
Professor | 4 | 7% |
Other | 12 | 21% |
Unknown | 15 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 42% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Business, Management and Accounting | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Other | 8 | 14% |
Unknown | 16 | 28% |