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Detection of circulating tumor cells using GeneScan analysis for antigen receptor gene rearrangements in canine lymphoma patients

Overview of attention for article published in Journal of Veterinary Medical Science, February 2016
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Title
Detection of circulating tumor cells using GeneScan analysis for antigen receptor gene rearrangements in canine lymphoma patients
Published in
Journal of Veterinary Medical Science, February 2016
DOI 10.1292/jvms.15-0433
Pubmed ID
Authors

Saaya HIYOSHI-KANEMOTO, Yuko GOTO-KOSHINO, Kenjiro FUKUSHIMA, Masashi TAKAHASHI, Hideyuki KANEMOTO, Kazuyuki UCHIDA, Yasuhito FUJINO, OHNO Koichi, Hajime TSUJIMOTO

Abstract

The presence of circulating tumor cells (CTCs) serves as a prognostic marker and indicator of disease relapse, as well as a means of evaluating treatment efficacy in human and canine lymphoma patients. As an extension of our previous study for the construction of clinically useful GeneScan system, we utilized the GeneScan system for detecting CTCs in canine lymphoma patients. Samples from the primary lesion and peripheral blood mononuclear cells (PBMCs) were obtained from 32 dogs with lymphoma at initial diagnosis. All samples were subjected to polymerase chain reaction (PCR) for antigen receptor gene rearrangements (PARR) followed by GeneScan analysis. Common clonal rearrangements with identical amplified fragments were detected in both the primary lesion and PBMCs in 19 of the 32 dogs (59.4%). However, the detection rate of CTCs varied among the anatomical classification of lymphoma studied. GeneScan analysis following PARR would facilitate studies on determining the clinical significance of CTCs in canine lymphoma patients.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 27%
Student > Bachelor 3 14%
Student > Ph. D. Student 3 14%
Professor 2 9%
Other 2 9%
Other 4 18%
Unknown 2 9%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 8 36%
Biochemistry, Genetics and Molecular Biology 4 18%
Medicine and Dentistry 2 9%
Mathematics 1 5%
Nursing and Health Professions 1 5%
Other 3 14%
Unknown 3 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2016.
All research outputs
#16,722,913
of 25,374,917 outputs
Outputs from Journal of Veterinary Medical Science
#1,213
of 3,546 outputs
Outputs of similar age
#178,886
of 312,017 outputs
Outputs of similar age from Journal of Veterinary Medical Science
#17
of 73 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,546 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,017 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.