↓ Skip to main content

The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth

Overview of attention for article published in EMBO Journal, May 2005
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

patent
5 patents
f1000
1 research highlight platform

Citations

dimensions_citation
348 Dimensions

Readers on

mendeley
189 Mendeley
citeulike
3 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth
Published in
EMBO Journal, May 2005
DOI 10.1038/sj.emboj.7600672
Pubmed ID
Authors

Helena Santos‐Rosa, Joanne Leung, Neil Grimsey, Sew Peak‐Chew, Symeon Siniossoglou

Abstract

Remodelling of the nuclear membrane is essential for the dynamic changes of nuclear architecture at different stages of the cell cycle and during cell differentiation. The molecular mechanism underlying the regulation of nuclear membrane biogenesis is not known. Here we show that Smp2, the yeast homologue of mammalian lipin, is a key regulator of nuclear membrane growth during the cell cycle. Smp2 is phosphorylated by Cdc28/Cdk1 and dephosphorylated by a nuclear/endoplasmic reticulum (ER) membrane-localized CPD phosphatase complex consisting of Nem1 and Spo7. Loss of either SMP2 or its dephosphorylated form causes transcriptional upregulation of key enzymes involved in lipid biosynthesis concurrent with a massive expansion of the nucleus. Conversely, constitutive dephosphorylation of Smp2 inhibits cell division. We show that Smp2 associates with the promoters of phospholipid biosynthetic enzymes in a Nem1-Spo7-dependent manner. Our data suggest that Smp2 is a critical factor in coordinating phospholipid biosynthesis at the nuclear/ER membrane with nuclear growth during the cell cycle.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 189 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Belgium 2 1%
Germany 1 <1%
United Kingdom 1 <1%
Austria 1 <1%
Finland 1 <1%
Singapore 1 <1%
Unknown 180 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 56 30%
Researcher 41 22%
Student > Bachelor 16 8%
Student > Master 16 8%
Student > Postgraduate 11 6%
Other 29 15%
Unknown 20 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 76 40%
Biochemistry, Genetics and Molecular Biology 65 34%
Medicine and Dentistry 6 3%
Chemistry 5 3%
Immunology and Microbiology 3 2%
Other 10 5%
Unknown 24 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2021.
All research outputs
#3,449,061
of 25,564,614 outputs
Outputs from EMBO Journal
#2,070
of 12,134 outputs
Outputs of similar age
#6,725
of 70,601 outputs
Outputs of similar age from EMBO Journal
#7
of 59 outputs
Altmetric has tracked 25,564,614 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,134 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.