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Severity of White Matter Hyperintensities and Effects on All-Cause Mortality in the Mayo Clinic Florida Familial Cerebrovascular Diseases Registry

Overview of attention for article published in Mayo Clinic Proceedings, March 2019
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Title
Severity of White Matter Hyperintensities and Effects on All-Cause Mortality in the Mayo Clinic Florida Familial Cerebrovascular Diseases Registry
Published in
Mayo Clinic Proceedings, March 2019
DOI 10.1016/j.mayocp.2018.10.024
Pubmed ID
Authors

Tasneem F. Hasan, Kevin M. Barrett, Thomas G. Brott, Mohammed K. Badi, Elizabeth R. Lesser, David O. Hodge, James F. Meschia

Abstract

To compare all-cause mortality rates across the severity range of white matter hyperintensities (WMH). Between October 26, 2010, and October 5, 2017, the ongoing Mayo Clinic Florida Familial Cerebrovascular Diseases Registry prospectively enrolled 1011 diverse participants with and without cerebrovascular disease. T2-weighted magnetic resonance imaging of the brain was used to evaluate WMH in 455 participants using the Fazekas scale. Fazekas deep WMH (FD) and periventricular WMH (FPV) scores (0-3 points) were assigned on the basis of WMH severity. Kaplan-Meier survival analyses, Cox proportional hazards models, and estimated hazard ratios compared survival rates across FD and FPV categories. The Fisher exact and χ2 tests evaluated the relationship of categorical variables, and the Kruskal-Wallis test measured the relationship of continuous variables across FD and FPV categories. All tests were performed at a P<.05 significance level. Over a median follow-up of 3.06 years (range, 0.00-6.96 years), 96 deaths occurred. Higher FD scores corresponded to a higher likelihood of mortality (P<.001). Participants with an FD score of 3 were 4.69 (95% CI, 2.60-8.46) times more likely to die compared with those with an FD score of 0. Participants with higher FPV scores had a higher likelihood of mortality (P<.001). Participants with an FPV score of 3 were 7.04 (95% CI, 3.39-14.62) times more likely to die compared with those with an FPV score of 0. Once adjusted, age and baseline functional status explained most of the survival differences among the FD scores. Associations between all-cause mortality rates across the severity range of WMH were observed in the Registry. Further studies are warranted to understand the clinical importance of WMH in other clinical populations.

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Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 17%
Student > Ph. D. Student 4 17%
Student > Bachelor 3 13%
Researcher 2 9%
Lecturer 1 4%
Other 1 4%
Unknown 8 35%
Readers by discipline Count As %
Medicine and Dentistry 6 26%
Computer Science 2 9%
Nursing and Health Professions 1 4%
Arts and Humanities 1 4%
Psychology 1 4%
Other 1 4%
Unknown 11 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2019.
All research outputs
#20,663,600
of 25,385,509 outputs
Outputs from Mayo Clinic Proceedings
#4,403
of 5,151 outputs
Outputs of similar age
#284,272
of 367,999 outputs
Outputs of similar age from Mayo Clinic Proceedings
#87
of 104 outputs
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