Title |
Improving survival in a large French ALS center cohort
|
---|---|
Published in |
Journal of Neurology, January 2012
|
DOI | 10.1007/s00415-011-6403-4 |
Pubmed ID | |
Authors |
Paul H. Gordon, François Salachas, Gaelle Bruneteau, Pierre-François Pradat, Lucette Lacomblez, Jesus Gonzalez-Bermejo, Capucine Morelot-Panzini, Thomas Similowski, Alexis Elbaz, Vincent Meininger |
Abstract |
The aim of this work was to determine whether survival changed during 2002-2009 at a French amyotrophic lateral sclerosis (ALS) center. We included all patients with ALS who were seen consecutively at the center from January 2002-May 2009. Participants were followed from date of first visit through death, date of censoring, or December 31, 2009, whichever occurred first. Cox proportional hazard models computed hazard ratios (HR; 95% confidence interval CI) of death, and flexible modeling of continuous predictors (splines) assessed trends in survival. We analyzed a total of 2,037 ALS patients, of whom 1,471 died before the end of follow-up. Median survival was 2.83 years from onset and 1.65 years from first visit. Compared to patients first seen before 2004, the HR of death was 0.97 (95% CI = 0.85-1.11, p = 0.6721) for patients first seen in 2004-2005, 0.96 (95% CI = 0.83-1.10, p = 0.5125) for 2006-2007, and 0.56 (95% CI = 0.46-0.69, p < 0.0001) after 2007, while adjusting for other survival predictors. Spline analysis confirmed that survival remained stable during 2002-2006, then markedly improved. The proportion of patients receiving non-invasive ventilation (NIV) increased from 16 (2004) to 51% (2008). At this large ALS center, survival improved after 2006. Because more aggressive use of NIV was the principal therapeutic adaptation, our data suggest that better survival resulted from improved respiratory care. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 3% |
Unknown | 37 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 16% |
Researcher | 6 | 16% |
Other | 5 | 13% |
Student > Master | 4 | 11% |
Professor > Associate Professor | 3 | 8% |
Other | 5 | 13% |
Unknown | 9 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 42% |
Agricultural and Biological Sciences | 3 | 8% |
Neuroscience | 2 | 5% |
Nursing and Health Professions | 1 | 3% |
Business, Management and Accounting | 1 | 3% |
Other | 4 | 11% |
Unknown | 11 | 29% |