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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress
|
|---|---|
| Published in |
Biology of the Cell, February 2012
|
| DOI | 10.1111/boc.201100055 |
| Pubmed ID | |
| Authors |
Richard Jäger, Mathieu J.M. Bertrand, Adrienne M. Gorman, Peter Vandenabeele, Afshin Samali |
| Abstract |
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the unfolded protein response (UPR). ER stress and the UPR are both implicated in numerous human diseases and pathologies. In spite of this, our knowledge of the molecular mechanisms that regulate cell fate following ER stress is limited. The UPR is initiated by three ER transmembrane receptors: PKR-like ER kinase (PERK), activating transcription factor (ATF) 6 and inositol-requiring enzyme 1 (IRE1). These proteins sense the accumulation of unfolded proteins and their activation triggers specific adaptive responses to resolve the stress. Intriguingly, the very same receptors can initiate signalling pathways that lead to apoptosis when the attempts to resolve the ER stress fail. In this review, we describe the known pro-apoptotic signalling pathways emanating from activated PERK, ATF6 and IRE1 and discuss how their signalling switches from an adaptive to a pro-apoptotic response. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 177 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 3 | 2% |
| Sweden | 1 | <1% |
| France | 1 | <1% |
| China | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 167 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 25% |
| Researcher | 21 | 12% |
| Student > Master | 20 | 11% |
| Student > Doctoral Student | 15 | 8% |
| Student > Bachelor | 15 | 8% |
| Other | 29 | 16% |
| Unknown | 33 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 74 | 42% |
| Biochemistry, Genetics and Molecular Biology | 32 | 18% |
| Medicine and Dentistry | 15 | 8% |
| Immunology and Microbiology | 7 | 4% |
| Neuroscience | 4 | 2% |
| Other | 11 | 6% |
| Unknown | 34 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2022.
All research outputs
#3,511,681
of 24,844,992 outputs
Outputs from Biology of the Cell
#35
of 741 outputs
Outputs of similar age
#20,915
of 160,201 outputs
Outputs of similar age from Biology of the Cell
#8
of 169 outputs
Altmetric has tracked 24,844,992 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 741 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,201 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.