| Title |
Preparation of peptide-loaded dendritic cells for cancer immunotherapy
|
|---|---|
| Published in |
Molecular Biotechnology, January 2003
|
| DOI | 10.1385/mb:25:1:95 |
| Pubmed ID | |
| Authors |
Michael A. Morse, Tim Clay, Kirsten Colling, H. Kim Lyerly |
| Abstract |
Dendritic cell-based vaccines are being evaluated in clinical trials to determine their ability to activate clinically relevant tumor antigen-specific immune responses. Although some groups isolate dendritic cells from peripheral blood, most have found it more efficient to generate large numbers from peripheral blood progenitors, particularly plastic adherent or CD14+ monocytes, in media supplemented with GM-CSF and IL-4. These DC may then be matured, if desired, and loaded with antigen, such as tumor-associated peptides, prior to administration. We describe the scheme that we are currently using to generate peptide-loaded dendritic cells for our clinical trials of cancer immunotherapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 10% |
| Unknown | 9 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 2 | 20% |
| Student > Ph. D. Student | 2 | 20% |
| Student > Master | 2 | 20% |
| Researcher | 2 | 20% |
| Student > Postgraduate | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 40% |
| Medicine and Dentistry | 2 | 20% |
| Immunology and Microbiology | 2 | 20% |
| Computer Science | 1 | 10% |
| Unknown | 1 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2013.
All research outputs
#7,473,822
of 22,849,304 outputs
Outputs from Molecular Biotechnology
#275
of 961 outputs
Outputs of similar age
#31,555
of 129,303 outputs
Outputs of similar age from Molecular Biotechnology
#11
of 23 outputs
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