Title |
CETP Inhibition: Does the Future Look Promising?
|
---|---|
Published in |
Current Cardiology Reports, September 2011
|
DOI | 10.1007/s11886-011-0218-x |
Pubmed ID | |
Authors |
Peter P. Toth |
Abstract |
Based on epidemiologic studies conducted throughout the world, it is established that there is an inverse relationship between high-density lipoprotein cholesterol (HDL-C) and risk for coronary artery disease (CAD). The incidence of low HDL-C is high and increasing throughout the world. A variety of pharmacologic approaches are being developed to therapeutically modulate serum levels of HDL-C. One controversial approach to this is the use of molecules that inhibit the activity of cholesteryl ester transfer protein (CETP), an enzyme involved in neutral lipid transfer between lipoproteins. The inhibition of CETP can lead to substantial elevations in HDL-C. Based on a number of considerations, including the complex relationship between loss of function mutations in CETP and risk for CAD and the clinical experience with torcetrapib, it is difficult to predict if CETP inhibition will be associated with reductions in rates of atherosclerosis disease progression and risk for cardiovascular events. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Greece | 1 | 7% |
Unknown | 14 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 27% |
Other | 2 | 13% |
Professor > Associate Professor | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Student > Doctoral Student | 1 | 7% |
Other | 2 | 13% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 40% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Business, Management and Accounting | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 20% |