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X Demographics
Mendeley readers
Attention Score in Context
| Title |
EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy
|
|---|---|
| Published in |
Stem Cell Reports, February 2016
|
| DOI | 10.1016/j.stemcr.2016.01.011 |
| Pubmed ID | |
| Authors |
Mengtao Li, Guang Lu, Jia Hu, Xue Shen, Jiabao Ju, Yuanxu Gao, Liujing Qu, Yan Xia, Yingyu Chen, Yun Bai |
| Abstract |
Self-renewal and differentiation of neural stem cells is essential for embryonic neurogenesis, which is associated with cell autophagy. However, the mechanism by which autophagy regulates neurogenesis remains undefined. Here, we show that Eva1a/Tmem166, an autophagy-related gene, regulates neural stem cell self-renewal and differentiation. Eva1a depletion impaired the generation of newborn neurons, both in vivo and in vitro. Conversely, overexpression of EVA1A enhanced newborn neuron generation and maturation. Moreover, Eva1a depletion activated the PIK3CA-AKT axis, leading to the activation of the mammalian target of rapamycin and the subsequent inhibition of autophagy. Furthermore, addition of methylpyruvate to the culture during neural stem cell differentiation rescued the defective embryonic neurogenesis induced by Eva1a depletion, suggesting that energy availability is a significant factor in embryonic neurogenesis. Collectively, these data demonstrated that EVA1A regulates embryonic neurogenesis by modulating autophagy. Our results have potential implications for understanding the pathogenesis of neurodevelopmental disorders caused by autophagy dysregulation. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 22% |
| Student > Ph. D. Student | 6 | 17% |
| Student > Bachelor | 5 | 14% |
| Other | 3 | 8% |
| Lecturer | 2 | 6% |
| Other | 6 | 17% |
| Unknown | 6 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Agricultural and Biological Sciences | 8 | 22% |
| Medicine and Dentistry | 3 | 8% |
| Neuroscience | 3 | 8% |
| Immunology and Microbiology | 2 | 6% |
| Other | 5 | 14% |
| Unknown | 7 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2023.
All research outputs
#17,365,807
of 25,483,400 outputs
Outputs from Stem Cell Reports
#1,900
of 2,146 outputs
Outputs of similar age
#189,131
of 312,236 outputs
Outputs of similar age from Stem Cell Reports
#42
of 46 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,146 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,236 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.