Title |
Role of T-cell activation in salt-sensitive hypertension
|
---|---|
Published in |
American Journal of Physiology: Heart & Circulatory Physiology, March 2019
|
DOI | 10.1152/ajpheart.00096.2019 |
Pubmed ID | |
Authors |
Jiafa Ren, Steven D Crowley |
Abstract |
The contributions of T lymphocytes to the pathogenesis of salt-sensitive hypertension has been well established. Under hypertensive stimuli, naïve T cells develop into different subsets, including Th1, Th2, Th17, Treg and cytotoxic CD8+ T cells, depending on the surrounding microenviroment in organs. Distinct subsets of T cells may play totally different roles in tissue damage and hypertension. The underlying mechanisms by which hypertensive stimuli activate naïve T cells involve many events and different organs, such as neoantigen presentation by dendritic cells, high salt concentration, the milieu of oxidative stress in the kidney and vasculature. Infiltrating and activated T subsets in injured organs, in turn, exert considerable impacts on tissue dysfunction, including sodium retention in the kidney, vascular stiffness and remodeling in vasculature. Therefore, a thorough knowledge of T cell actions in hypertension may provide novel insights for the development of new therapeutic strategies for patients with hypertension. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 50% |
Argentina | 1 | 7% |
United Kingdom | 1 | 7% |
Unknown | 5 | 36% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 7 | 50% |
Members of the public | 5 | 36% |
Science communicators (journalists, bloggers, editors) | 2 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 20% |
Student > Bachelor | 4 | 8% |
Professor > Associate Professor | 4 | 8% |
Student > Master | 4 | 8% |
Researcher | 3 | 6% |
Other | 9 | 18% |
Unknown | 17 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 25% |
Agricultural and Biological Sciences | 3 | 6% |
Immunology and Microbiology | 3 | 6% |
Nursing and Health Professions | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 4 | 8% |
Unknown | 24 | 47% |