Title |
Confirmation of novel type 1 diabetes risk loci in families
|
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Published in |
Diabetologia, January 2012
|
DOI | 10.1007/s00125-012-2450-3 |
Pubmed ID | |
Authors |
J. D. Cooper, J. M. M. Howson, D. Smyth, N. M. Walker, H. Stevens, J. H. M. Yang, J.-X. She, G. S. Eisenbarth, M. Rewers, J. A. Todd, B. Akolkar, P. Concannon, H. A. Erlich, C. Julier, G. Morahan, J. Nerup, C. Nierras, F. Pociot, S. S. Rich, the Type 1 Diabetes Genetics Consortium |
Abstract |
Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study. |
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