| Title |
The renewed battle against RAS-mutant cancers
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, February 2016
|
| DOI | 10.1007/s00018-016-2155-8 |
| Pubmed ID | |
| Authors |
Fuquan Zhang, Jit Kong Cheong |
| Abstract |
The RAS genes encode for members of a large superfamily of guanosine-5'-triphosphate (GTP)-binding proteins that control diverse intracellular signaling pathways to promote cell proliferation. Somatic mutations in the RAS oncogenes are the most common activating lesions found in human cancers. These mutations invariably result in the gain-of-function of RAS by impairing GTP hydrolysis and are frequently associated with poor responses to standard cancer therapies. In this review, we summarize key findings of past and present landmark studies that have deepened our understanding of the RAS biology in the context of oncogenesis. We also discuss how emerging areas of research could further bolster a renewed global effort to target the largely undruggable oncogenic RAS and/or its activated downstream effector signaling cascades to achieve better treatment outcomes for RAS-mutant cancer patients. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Spain | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 65 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 30% |
| Researcher | 16 | 23% |
| Student > Bachelor | 8 | 12% |
| Student > Master | 5 | 7% |
| Other | 3 | 4% |
| Other | 9 | 13% |
| Unknown | 7 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 48% |
| Agricultural and Biological Sciences | 14 | 20% |
| Medicine and Dentistry | 8 | 12% |
| Chemistry | 2 | 3% |
| Neuroscience | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 7 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2022.
All research outputs
#4,863,939
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#921
of 4,151 outputs
Outputs of similar age
#72,095
of 299,655 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#12
of 58 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,655 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.