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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries
|
|---|---|
| Published in |
Nature Communications, February 2016
|
| DOI | 10.1038/ncomms10845 |
| Pubmed ID | |
| Authors |
Josephine Bowles, Chun-Wei Feng, Kim Miles, Jessica Ineson, Cassy Spiller, Peter Koopman |
| Abstract |
Substantial evidence exists that during fetal ovarian development in mammals, retinoic acid (RA) induces germ cells to express the pre-meiotic marker Stra8 and enter meiosis, and that these effects are prevented in the fetal testis by the RA-degrading P450 enzyme CYP26B1. Nonetheless, the role of RA has been disputed principally because germ cells in embryos lacking two major RA-synthesizing enzymes, ALDH1A2 and ALDH1A3, remain able to enter meiosis. Here we show that a third RA-synthesizing enzyme, ALDH1A1, is expressed in fetal ovaries, providing a likely source of RA in the absence of ALDH1A2 and ALDH1A3. In ovaries lacking ALDH1A1, the onset of germ cell meiosis is delayed. Our data resolve the conundrum posed by conflicting published data sets and reconfirm the model that meiosis is triggered by endogenous RA in the developing ovary. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Australia | 1 | 25% |
| Japan | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Members of the public | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 1% |
| United Kingdom | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 70 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 25% |
| Researcher | 14 | 19% |
| Student > Bachelor | 9 | 12% |
| Student > Master | 5 | 7% |
| Professor > Associate Professor | 4 | 5% |
| Other | 8 | 11% |
| Unknown | 15 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 38% |
| Agricultural and Biological Sciences | 19 | 26% |
| Medicine and Dentistry | 3 | 4% |
| Nursing and Health Professions | 2 | 3% |
| Veterinary Science and Veterinary Medicine | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 14 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2016.
All research outputs
#12,752,034
of 22,849,304 outputs
Outputs from Nature Communications
#37,578
of 47,053 outputs
Outputs of similar age
#130,775
of 297,895 outputs
Outputs of similar age from Nature Communications
#662
of 875 outputs
Altmetric has tracked 22,849,304 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 47,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,895 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 875 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.