| Title |
The intercellular adhesin locus ica is present in clinical isolates of Staphylococcus aureus from bacteremic patients with infected and uninfected prosthetic joints
|
|---|---|
| Published in |
Medical Microbiology and Immunology, April 2001
|
| DOI | 10.1007/s430-001-8018-5 |
| Pubmed ID | |
| Authors |
Vance G. Fowler Jr, Paul D. Fey, L. Barth Reller, Anna Lisa Chamis, G. Ralph Corey, Mark E. Rupp |
| Abstract |
Although polysaccharide intercellular adhesin (PIA) is thought to be crucial in the pathogenesis of prosthetic device infections caused by Staphylococcus epidermidis, its role in prosthetic device infections caused by Staphylococcus aureus is unknown. To assess the clinical impact of PIA production, isolates from 15 prospectively identified cases of S. aureus bacteremia in patients with prosthetic joints (8 infected, 7 uninfected) were characterized for biofilm production, hemagglutination, and the presence of a 419-bp amplification product within icaA. Although icaA was present in all 15 isolates, none of the isolates produced hemagglutination and only one isolate (from a patient with an uninfected prosthetic device) weakly produced biofilm in vitro. These results support the observation that the ica locus is conserved between S. epidermidis and S. aureus and that PIA may be expressed only under in vivo conditions. Future investigations should include animal models to approximate the complex milieu surrounding implanted prosthetic medical devices. |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 18% |
| Student > Bachelor | 6 | 15% |
| Student > Master | 5 | 13% |
| Researcher | 5 | 13% |
| Lecturer | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 9 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 18% |
| Medicine and Dentistry | 7 | 18% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Immunology and Microbiology | 4 | 10% |
| Engineering | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 12 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2021.
All research outputs
#8,535,684
of 25,377,790 outputs
Outputs from Medical Microbiology and Immunology
#166
of 645 outputs
Outputs of similar age
#14,512
of 43,237 outputs
Outputs of similar age from Medical Microbiology and Immunology
#2
of 3 outputs
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