Title |
HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia
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Published in |
BMC Cancer, January 2012
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DOI | 10.1186/1471-2407-12-36 |
Pubmed ID | |
Authors |
Mariska Bierkens, Saskia M Wilting, Wessel N van Wieringen, Mark A van de Wiel, Bauke Ylstra, Chris JLM Meijer, Peter JF Snijders, Renske DM Steenbergen |
Abstract |
The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 31% |
Professor | 5 | 13% |
Student > Master | 4 | 10% |
Researcher | 4 | 10% |
Student > Doctoral Student | 2 | 5% |
Other | 6 | 15% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 33% |
Agricultural and Biological Sciences | 8 | 21% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Nursing and Health Professions | 2 | 5% |
Business, Management and Accounting | 1 | 3% |
Other | 4 | 10% |
Unknown | 7 | 18% |