Title |
An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition
|
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Published in |
BMC Cancer, October 2011
|
DOI | 10.1186/1471-2407-11-461 |
Pubmed ID | |
Authors |
Lauren MF Merlo, Rachelle E Kosoff, Kristin L Gardiner, Carlo C Maley |
Abstract |
The evolutionary dynamics between interacting heterogeneous cell types are fundamental properties of neoplastic progression but can be difficult to measure and quantify. Cancers are heterogeneous mixtures of mutant clones but the direct effect of interactions between these clones is rarely documented. The implicit goal of most preventive interventions is to bias competition in favor of normal cells over neoplastic cells. However, this is rarely explicitly tested. Here we have developed a cell culture competition model to allow for direct observation of the effect of chemopreventive or therapeutic agents on two interacting cell types. We have examined competition between normal and Barrett's esophagus cell lines, in the hopes of identifying a system that could screen for potential chemopreventive agents. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 4% |
United States | 1 | 2% |
France | 1 | 2% |
Unknown | 47 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 27% |
Researcher | 10 | 20% |
Student > Master | 9 | 18% |
Student > Doctoral Student | 3 | 6% |
Student > Bachelor | 3 | 6% |
Other | 5 | 10% |
Unknown | 7 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 27% |
Agricultural and Biological Sciences | 13 | 25% |
Medicine and Dentistry | 9 | 18% |
Chemical Engineering | 2 | 4% |
Engineering | 2 | 4% |
Other | 4 | 8% |
Unknown | 7 | 14% |