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The role of thrombin receptors PAR1 and PAR4 for PAI-1 storage, synthesis and secretion by human platelets

Overview of attention for article published in Thrombosis Research, January 2012
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Title
The role of thrombin receptors PAR1 and PAR4 for PAI-1 storage, synthesis and secretion by human platelets
Published in
Thrombosis Research, January 2012
DOI 10.1016/j.thromres.2011.12.021
Pubmed ID
Authors

Martina Nylander, Abdimajid Osman, Sofia Ramström, Emma Åklint, Anders Larsson, Tomas L. Lindahl

Abstract

Arterial thrombi contain more platelets than venous thrombi and are more resistant to fibrinolysis. This resistance could partly be due to plasminogen activator inhibitor 1 (PAI-1) secreted by platelets. The aim of this study was to elucidate differences between thrombin receptors protease-activated receptor (PAR) 1 and 4 and platelet storage, secretion and synthesis of platelet PAI-1, as compared to other platelet α-granule proteins such as VEGF and endostatin.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 4%
Czechia 1 4%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 29%
Student > Ph. D. Student 7 25%
Student > Doctoral Student 2 7%
Student > Bachelor 2 7%
Professor 2 7%
Other 2 7%
Unknown 5 18%
Readers by discipline Count As %
Medicine and Dentistry 14 50%
Agricultural and Biological Sciences 4 14%
Biochemistry, Genetics and Molecular Biology 3 11%
Immunology and Microbiology 1 4%
Chemistry 1 4%
Other 0 0%
Unknown 5 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2012.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Thrombosis Research
#3,992
of 4,256 outputs
Outputs of similar age
#230,036
of 252,183 outputs
Outputs of similar age from Thrombosis Research
#19
of 23 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,256 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,183 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.