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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application
|
|---|---|
| Published in |
Clinical Materials, January 2012
|
| DOI | 10.1016/j.biomaterials.2011.12.025 |
| Pubmed ID | |
| Authors |
Zhi-Yong Zhang, Swee-Hin Teoh, James H.P. Hui, Nicholas M. Fisk, Mahesh Choolani, Jerry K.Y. Chan |
| Abstract |
Mesenchymal stem cells (MSCs) have become one of the most promising cell sources for bone tissue engineering (BTE) applications. In this review, we first highlight recent progress in the understanding of MSC biology, their in vivo niche, multi-faceted contribution to fracture healing and bone re-modelling, and their role in BTE. A literature review from clinicaltrials.gov and Pubmed on clinical usage of MSC for both orthopedic and non-orthopedic indications suggests that translational use of MSC for BTE indications is likely to bear fruit in the ensuing decade. Last, we disscuss the profound influence of ontological and antomical origins of MSC on their proliferation and osteogenesis and demonstrated human fetal MSC (hfMSC) as a superior cellular candidate for off-the-shelf BTE applications. This relates to their superior proliferation capacity, more robust osteogenic potential and lower immunogenecity, as compared to MSC from perinatal and postnatal sources. Furthermore, we discuss our experience in developing a hfMSC based BTE strategy with the integrated use of bioreactor-based dynamic priming within macroporous scaffolds, now ready for evaluation in clinical trials. In conclusion, hfMSC is likely the most promising cell source for allogeneic based BTE application, with proven advantages compared to other MSC based ones. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Singapore | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Colombia | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Ireland | 1 | <1% |
| Sweden | 1 | <1% |
| Singapore | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Belgium | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 128 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 27% |
| Student > Master | 29 | 21% |
| Researcher | 17 | 12% |
| Student > Bachelor | 13 | 9% |
| Other | 6 | 4% |
| Other | 18 | 13% |
| Unknown | 18 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 24% |
| Agricultural and Biological Sciences | 30 | 22% |
| Engineering | 14 | 10% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Materials Science | 11 | 8% |
| Other | 14 | 10% |
| Unknown | 25 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2022.
All research outputs
#7,525,084
of 25,838,141 outputs
Outputs from Clinical Materials
#4,299
of 10,826 outputs
Outputs of similar age
#61,328
of 252,310 outputs
Outputs of similar age from Clinical Materials
#51
of 117 outputs
Altmetric has tracked 25,838,141 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 10,826 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,310 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.