| Title |
Acute inhibition of iron bioavailability by zinc: studies in humans
|
|---|---|
| Published in |
BioMetals, February 2012
|
| DOI | 10.1007/s10534-012-9524-z |
| Pubmed ID | |
| Authors |
Manuel Olivares, Fernando Pizarro, Manuel Ruz, Daniel López de Romaña |
| Abstract |
Iron (Fe) and zinc (Zn) deficiencies constitute two of the most important nutritional and public health problems affecting developing countries. Combined supplementation or fortification with Zn and Fe are strategies that can be used to improve the Zn and Fe status of a population. However, there is concern about potential negative interactions between these two micronutrients due to a competitive binding to DMT1 and Zip14 transporter. Studies performed in humans have shown an inhibitory effect of Zn on Fe absorption when both minerals are given together as a solution in fasting conditions. We found that at low doses of iron (0.5 mg) the threshold for the inhibition of iron bioavailability was at a Zn:Fe wt/wt ratio ≥5.9:1, whereas at higher doses of Fe (10 mg) this inhibition occurred at 1:1 Zn:Fe wt/wt ratio. This differential response could be explained by the variation in the abundance of both cations as they compete for a limited number of shared transporters at the enterocyte. Conflicting results have been obtained when this interaction was studied in different food matrices. A negative interaction was not observed when Fe and Zn were provided in a composite hamburger meal, premature formula, human milk, or cow milk. A decrease on Fe absorption was observed in only 1 of 3 studies when Fe and Zn were supplied in wheat flour. The possibility of a negative interaction should be considered for supplementation or fortification programs with both microminerals. |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Netherlands | 1 | 1% |
| France | 1 | 1% |
| Indonesia | 1 | 1% |
| Denmark | 1 | 1% |
| India | 1 | 1% |
| Unknown | 84 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 16% |
| Student > Ph. D. Student | 12 | 13% |
| Student > Master | 12 | 13% |
| Student > Bachelor | 7 | 8% |
| Professor > Associate Professor | 5 | 5% |
| Other | 18 | 20% |
| Unknown | 22 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 26% |
| Medicine and Dentistry | 16 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Nursing and Health Professions | 5 | 5% |
| Chemistry | 4 | 4% |
| Other | 10 | 11% |
| Unknown | 25 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2012.
All research outputs
#20,154,661
of 22,662,201 outputs
Outputs from BioMetals
#520
of 640 outputs
Outputs of similar age
#223,732
of 247,293 outputs
Outputs of similar age from BioMetals
#5
of 7 outputs
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So far Altmetric has tracked 640 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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