| Title |
The pathogenesis of early retinal changes of diabetic retinopathy
|
|---|---|
| Published in |
Documenta Ophthalmologica, February 2012
|
| DOI | 10.1007/s10633-011-9305-y |
| Pubmed ID | |
| Authors |
G. B. Arden, S. Sivaprasad |
| Abstract |
Recent successful trials of antibodies to vascular endothelial growth factor (VEGF) in diabetic retinopathy implicate this cytokine as a major cause of diabetic retinopathy (DR) and diabetic macular oedema (DME). The mechanisms which cause VEGF to be over-expressed to cause the vasculopathy are not entirely clear. This review explores the earliest changes to the retina in DR and the factors that predispose or prevent DR, including sleep apnoea, receptor degenerations laser treatment and VEGF polymorphism. The review also presents the evidence that retinal hypoxia, existing in the earliest stages, causes DR. This hypoxia is much increased by dark adaptation, indicating a new and possibly superior therapy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Netherlands | 1 | 1% |
| Brazil | 1 | 1% |
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Russia | 1 | 1% |
| Unknown | 74 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 19% |
| Student > Master | 15 | 19% |
| Student > Ph. D. Student | 14 | 18% |
| Student > Bachelor | 8 | 10% |
| Student > Postgraduate | 7 | 9% |
| Other | 12 | 15% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 44% |
| Agricultural and Biological Sciences | 10 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Neuroscience | 4 | 5% |
| Computer Science | 3 | 4% |
| Other | 10 | 13% |
| Unknown | 12 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2017.
All research outputs
#7,169,715
of 22,662,201 outputs
Outputs from Documenta Ophthalmologica
#59
of 456 outputs
Outputs of similar age
#68,973
of 247,565 outputs
Outputs of similar age from Documenta Ophthalmologica
#1
of 2 outputs
Altmetric has tracked 22,662,201 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 456 research outputs from this source. They receive a mean Attention Score of 2.4. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,565 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them