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Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages

Overview of attention for article published in The Journal of Allergy and Clinical Immunology, February 2016
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Title
Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages
Published in
The Journal of Allergy and Clinical Immunology, February 2016
DOI 10.1016/j.jaci.2015.12.1305
Pubmed ID
Authors

Maximilian Schieck, Jan P. Schouten, Sven Michel, Kathrin Suttner, Antoaneta A. Toncheva, Vincent D. Gaertner, Thomas Illig, Simone Lipinski, Andre Franke, Michael Klintschar, Omer Kalayci, Umit M. Sahiner, Esra Birben, Erik Melén, Göran Pershagen, Maxim B. Freidin, Ludmila M. Ogorodova, Raquel Granell, John Henderson, Bert Brunekreef, Henriëtte A. Smit, Christian Vogelberg, Andrea von Berg, Albrecht Bufe, Andrea Heinzmann, Otto Laub, Ernst Rietschel, Burkhard Simma, Jon Genuneit, Danny Jonigk, Dirkje S. Postma, Gerard H. Koppelman, Judith M. Vonk, Wim Timens, H. Marike Boezen, Michael Kabesch

Abstract

Asthma is a disease affecting more boys than girls in childhood and more women than men in adulthood. The mechanisms behind these sex-specific differences are not yet understood. We analyzed whether and how genetic factors contribute to sex-specific predisposition to childhood-onset asthma. Interactions between sex and polymorphisms on childhood asthma risk were evaluated in the Multicentre Asthma Genetics in Childhood Study (MAGICS)/Phase II International Study of Asthma and Allergies in Childhood (ISAAC II) population on a genome-wide level, and findings were validated in independent populations. Genetic fine mapping of sex-specific asthma association signals was performed, and putatively causal polymorphisms were characterized in vitro by using electrophoretic mobility shift and luciferase activity assays. Gene and protein expression of the identified gene doublesex and mab-3 related transcription factor 1 (DMRT1) were measured in different human tissues by using quantitative real-time PCR and immunohistochemistry. Polymorphisms in the testis-associated gene DMRT1 displayed interactions with sex on asthma status in a population of primarily clinically defined asthmatic children and nonasthmatic control subjects (lowest P = 5.21 × 10(-6)). Replication of this interaction was successful in 2 childhood populations clinically assessed for asthma but showed heterogeneous results in other population-based samples. Polymorphism rs3812523 located in the putative DMRT1 promoter was associated with allele-specific changes in transcription factor binding and promoter activity in vitro. DMRT1 expression was observed not only in the testis but also in lung macrophages. DMRT1 might influence sex-specific patterns of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential involvement in hormone or immune cell regulation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 2%
Germany 1 2%
Unknown 47 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 20%
Student > Doctoral Student 6 12%
Student > Bachelor 5 10%
Student > Master 4 8%
Professor > Associate Professor 3 6%
Other 9 18%
Unknown 12 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 20%
Medicine and Dentistry 9 18%
Agricultural and Biological Sciences 4 8%
Psychology 4 8%
Immunology and Microbiology 2 4%
Other 4 8%
Unknown 16 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2017.
All research outputs
#14,937,796
of 25,411,814 outputs
Outputs from The Journal of Allergy and Clinical Immunology
#8,815
of 11,258 outputs
Outputs of similar age
#150,501
of 312,219 outputs
Outputs of similar age from The Journal of Allergy and Clinical Immunology
#133
of 221 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,258 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,219 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 221 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.