Title |
[Heterogeneities in intracellular Ca2+ pools among different arterial smooth muscle cells and its possible role in vascular reactivities in rat].
|
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Published in |
Zhongguo yi xue ke xue yuan xue bao Acta Academiae Medicinae Sinicae, June 1996
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DOI | 10.1007/s003359900340 |
Pubmed ID | |
Authors |
J Cao, M Chen, Q Wang |
Abstract |
The differences in intracellular Ca2+ pool capacities, the mutual relations between different agonist-sensitive Ca2+ pools (ASCaP) and between ASCaP and caffeine-sensitive Ca2+ pool (CSCaP), and the possible role of Ca2+ pool capacity in vascular reactivities in different isolated artery rings of rat in Ca(2+)-free media were studied by using the tension of vascular smooth muscle as an indicator of Ca2+ release. The study showed the following findings: (1) the Ca2+ pools were significantly different in capacities in different arteries (renal artery > mesenteric artery > caudal artery > aorta > pulmonary artery); (2) different ASCaPs were partially "overlapped", i.e., when one ASCaP was depleted, other kind of agonist could still induce a small but significant Ca2+ release; (3) the CSCaP was present in all the arteries tested, but it was not the same pool with the ASCaP; (4) there were no high-K+ depolarization-induced Ca2+ release in all the arteries tested and (5) there was a positive correlation between the maximal contraction (Emax expressed as mg force/mg muscle wet weight) and the Ca2+ pool capacities, suggesting that there is a role of Ca2+ pool capacities in the vascular contractilities. |
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Netherlands | 1 | 2% |
Ireland | 1 | 2% |
Kenya | 1 | 2% |
Brazil | 1 | 2% |
Argentina | 1 | 2% |
Unknown | 58 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 17% |
Student > Master | 9 | 14% |
Professor | 7 | 11% |
Student > Ph. D. Student | 6 | 10% |
Other | 5 | 8% |
Other | 11 | 17% |
Unknown | 14 | 22% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 4 | 6% |
Chemistry | 2 | 3% |
Business, Management and Accounting | 2 | 3% |
Other | 7 | 11% |
Unknown | 14 | 22% |