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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach
|
|---|---|
| Published in |
Scientific Reports, April 2019
|
| DOI | 10.1038/s41598-018-36689-2 |
| Pubmed ID | |
| Authors |
Laura Ramo-Fernández, Christina Boeck, Alexandra M. Koenig, Katharina Schury, Elisabeth B. Binder, Harald Gündel, Jöerg M. Fegert, Alexander Karabatsiakis, Iris-Tatjana Kolassa |
| Abstract |
While biological alterations associated with childhood maltreatment (CM) have been found in affected individuals, it remains unknown to what degree these alterations are biologically transmitted to the next generation. We investigated intergenerational effects of maternal CM on DNA methylation and gene expression in N = 113 mother-infant dyads shortly after parturition, additionally accounting for the role of the FKBP5 rs1360780 genotype. Using mass array spectrometry, we assessed the DNA methylation of selected stress-response-associated genes (FK506 binding protein 51 [FKBP5], glucocorticoid receptor [NR3C1], corticotropin-releasing hormone receptor 1 [CRHR1]) in isolated immune cells from maternal blood and neonatal umbilical cord blood. In mothers, CM was associated with decreased levels of DNA methylation of FKBP5 and CRHR1 and increased NR3C1 methylation, but not with changes in gene expression profiles. Rs1360780 moderated the FKBP5 epigenetic CM-associated regulation profiles in a gene × environment interaction. In newborns, we found no evidence for any intergenerational transmission of CM-related methylation profiles for any of the investigated epigenetic sites. These findings support the hypothesis of a long-lasting impact of CM on the biological epigenetic regulation of stress-response mediators and suggest for the first time that these specific epigenetic patterns might not be directly transmitted to the next generation. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 33% |
| Canada | 2 | 7% |
| United Kingdom | 2 | 7% |
| Australia | 2 | 7% |
| Norway | 1 | 3% |
| Greece | 1 | 3% |
| Switzerland | 1 | 3% |
| Unknown | 11 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 53% |
| Scientists | 10 | 33% |
| Practitioners (doctors, other healthcare professionals) | 4 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 128 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 24 | 19% |
| Student > Ph. D. Student | 16 | 13% |
| Researcher | 13 | 10% |
| Student > Bachelor | 13 | 10% |
| Student > Doctoral Student | 8 | 6% |
| Other | 18 | 14% |
| Unknown | 36 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 19 | 15% |
| Medicine and Dentistry | 15 | 12% |
| Biochemistry, Genetics and Molecular Biology | 13 | 10% |
| Neuroscience | 9 | 7% |
| Social Sciences | 7 | 5% |
| Other | 20 | 16% |
| Unknown | 45 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#1,705,175
of 24,954,788 outputs
Outputs from Scientific Reports
#15,879
of 136,704 outputs
Outputs of similar age
#37,553
of 356,920 outputs
Outputs of similar age from Scientific Reports
#440
of 3,607 outputs
Altmetric has tracked 24,954,788 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 136,704 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 356,920 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 3,607 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.