Title |
Dexamethasone/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices
|
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Published in |
Clinical Materials, April 2002
|
DOI | 10.1016/s0142-9612(01)00291-5 |
Pubmed ID | |
Authors |
T Hickey, D Kreutzer, D.J Burgess, F Moussy |
Abstract |
The purpose of this research was to develop polylactic-co-glycolic acid (PLGA) microspheres for continuous delivery of dexamethasone for over a 1-month period, in an effort to suppress the acute and chronic inflammatory reactions to implants such as biosensors, which interfere with their functionality. The microspheres were prepared using an oil-in-water emulsion technique. The oil phase was composed of 9:1 dichloromethane to methanol with dissolved PLGA and dexamethasone. Some microspheres were predegraded for 1 or 2 weeks. Ten percent of polyethylene glycol was added to the oil phase in alternative formulations to delay drug release. The in vitro release studies were performed in a constant temperature (37 C) warm room, in phosphate-buffered saline at sink conditions. Drug loading and release rates were determined by HPLC-UV analysis. The standard microsphere systems did not provide the desired release profile since, following an initial burst release, a delay of 2 weeks occurred prior to continuous drug release. Predegraded microspheres started to release dexamethasone immediately but the rate of release decreased after only 2 weeks. A mixed standard and predegraded microsphere system was used to avoid this delay and to provide continuous release of dexamethasone for 1 month. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 3 | 2% |
United States | 3 | 2% |
Iran, Islamic Republic of | 2 | 1% |
United Kingdom | 1 | <1% |
Belgium | 1 | <1% |
Austria | 1 | <1% |
Unknown | 179 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 56 | 29% |
Student > Master | 29 | 15% |
Student > Bachelor | 17 | 9% |
Researcher | 15 | 8% |
Student > Doctoral Student | 13 | 7% |
Other | 30 | 16% |
Unknown | 30 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 34 | 18% |
Agricultural and Biological Sciences | 25 | 13% |
Chemistry | 19 | 10% |
Materials Science | 17 | 9% |
Medicine and Dentistry | 17 | 9% |
Other | 38 | 20% |
Unknown | 40 | 21% |