| Title |
Fecal calprotectin: its scope and utility in the management of inflammatory bowel disease
|
|---|---|
| Published in |
Journal of Gastroenterology, February 2016
|
| DOI | 10.1007/s00535-016-1182-4 |
| Pubmed ID | |
| Authors |
Shapur Ikhtaire, Mohammad Sharif Shajib, Walter Reinisch, Waliul Islam Khan |
| Abstract |
Gastrointestinal symptoms such as abdominal pain, dyspepsia, and diarrhea are relatively nonspecific and a common cause for seeking medical attention. To date, it is challenging for physicians to differentiate between functional and organic gastrointestinal conditions and it involves the use of serological and endoscopic techniques. Therefore, a simple, noninvasive, inexpensive, and effective test would be of utmost importance in clinical practice. Fecal calprotectin (FC) is considered to be a reliable biomarker that fulfills these criteria. FC can detect intestinal inflammation, and its level correlates well with macroscopic and histological inflammation as detected by colonoscopy and biopsies, respectively. FC has a decent diagnostic accuracy for differentiating organic diseases and functional disorders because of its excellent negative predictive value in ruling out inflammatory bowel disease (IBD) in symptomatic undiagnosed patients. There is accumulating evidence that FC has been effectively used to monitor the natural course of IBD, to predict relapse, and to see the response to treatment. This novel biomarker has the ability to assess mucosal healing (MH), which is a therapeutic goal in IBD management. A literature search was carried out using PubMed with the keywords FC, IBD, intestinal inflammation, and MH. In our review, we provide an overview of the utility and scope of FC as a biomarker in patients with IBD as well as undiagnosed patients with lower gastrointestinal symptoms. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Arab Emirates | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 121 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 12% |
| Student > Master | 14 | 11% |
| Other | 13 | 11% |
| Student > Ph. D. Student | 13 | 11% |
| Student > Bachelor | 13 | 11% |
| Other | 28 | 23% |
| Unknown | 26 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 34% |
| Biochemistry, Genetics and Molecular Biology | 14 | 11% |
| Agricultural and Biological Sciences | 8 | 7% |
| Immunology and Microbiology | 6 | 5% |
| Nursing and Health Professions | 3 | 2% |
| Other | 15 | 12% |
| Unknown | 35 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2022.
All research outputs
#3,851,680
of 23,427,600 outputs
Outputs from Journal of Gastroenterology
#134
of 1,114 outputs
Outputs of similar age
#59,148
of 299,235 outputs
Outputs of similar age from Journal of Gastroenterology
#4
of 24 outputs
Altmetric has tracked 23,427,600 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,114 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.