Title |
18F-Fluoromisonidazole positron emission tomography may differentiate glioblastoma multiforme from less malignant gliomas
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Published in |
European Journal of Nuclear Medicine and Molecular Imaging, February 2012
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DOI | 10.1007/s00259-011-2037-0 |
Pubmed ID | |
Authors |
Kenji Hirata, Shunsuke Terasaka, Tohru Shiga, Naoya Hattori, Keiichi Magota, Hiroyuki Kobayashi, Shigeru Yamaguchi, Kiyohiro Houkin, Shinya Tanaka, Yuji Kuge, Nagara Tamaki |
Abstract |
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor and its prognosis is significantly poorer than those of less malignant gliomas. Pathologically, necrosis is one of the most important characteristics that differentiate GBM from lower grade gliomas; therefore, we hypothesized that (18)F fluoromisonidazole (FMISO), a radiotracer for hypoxia imaging, accumulates in GBM but not in lower grade gliomas. We aimed to evaluate the diagnostic value of FMISO positron emission tomography (PET) for the differential diagnosis of GBM from lower grade gliomas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
United Kingdom | 1 | 2% |
Netherlands | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 53 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 16% |
Student > Ph. D. Student | 8 | 14% |
Student > Postgraduate | 6 | 11% |
Professor > Associate Professor | 6 | 11% |
Student > Master | 6 | 11% |
Other | 15 | 26% |
Unknown | 7 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 49% |
Agricultural and Biological Sciences | 9 | 16% |
Neuroscience | 4 | 7% |
Engineering | 3 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Other | 3 | 5% |
Unknown | 8 | 14% |