| Title |
The role of the Major Histocompatibility Complex in the spread of contagious cancers
|
|---|---|
| Published in |
Mammalian Genome, October 2010
|
| DOI | 10.1007/s00335-010-9294-2 |
| Pubmed ID | |
| Authors |
Katherine Belov |
| Abstract |
Major Histocompatibility Complex (MHC) genes play a key role in immune response to infectious diseases, immunosurveillance, and self/nonself recognition. Matching MHC alleles is critical for organ transplantation, while changes in the MHC profile of tumour cells allow effective evasion of the immune response. Two unique cancers have exploited these features to become transmissible. In this review I discuss the functional role of MHC molecules in the emergence and evolution of Devil Facial Tumour Disease (DFTD) and Canine Transmissible Venereal Tumour (CTVT). High levels of genetic diversity at MHC genes play a critical role in protecting populations of vertebrate species from contagious cancer. However, species that have undergone genetic bottlenecks and have lost diversity at MHC genes are at risk of transmissible tumours. Moreover, evolution and selection for tumour variants capable of evading the immune response allow contagious cancers to cross MHC barriers. Transmissible cancers are rare but they can provide unique insights into the genetics and immunology of tumours and organ transplants. |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Hungary | 1 | 1% |
| Chile | 1 | 1% |
| Germany | 1 | 1% |
| Japan | 1 | 1% |
| United Kingdom | 1 | 1% |
| Unknown | 87 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 20% |
| Student > Bachelor | 19 | 20% |
| Researcher | 12 | 13% |
| Student > Doctoral Student | 7 | 7% |
| Other | 6 | 6% |
| Other | 17 | 18% |
| Unknown | 15 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 36 | 38% |
| Veterinary Science and Veterinary Medicine | 12 | 13% |
| Biochemistry, Genetics and Molecular Biology | 10 | 11% |
| Immunology and Microbiology | 8 | 8% |
| Medicine and Dentistry | 6 | 6% |
| Other | 7 | 7% |
| Unknown | 16 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2023.
All research outputs
#6,666,779
of 23,556,846 outputs
Outputs from Mammalian Genome
#287
of 1,139 outputs
Outputs of similar age
#31,523
of 100,922 outputs
Outputs of similar age from Mammalian Genome
#4
of 7 outputs
Altmetric has tracked 23,556,846 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,139 research outputs from this source. They receive a mean Attention Score of 4.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,922 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.