| Title |
Age-Related Changes in Processing Simultaneous Amplitude Modulated Sounds Assessed Using Envelope Following Responses
|
|---|---|
| Published in |
Journal of the Association for Research in Otolaryngology, February 2016
|
| DOI | 10.1007/s10162-016-0554-z |
| Pubmed ID | |
| Authors |
Aravindakshan Parthasarathy, Jesyin Lai, Edward L. Bartlett |
| Abstract |
Listening conditions in the real world involve segregating the stimuli of interest from competing auditory stimuli that differ in their sound level and spectral content. It is in these conditions of complex spectro-temporal processing that listeners with age-related hearing loss experience the most difficulties. Envelope following responses (EFRs) provide objective neurophysiological measures of auditory processing. EFRs were obtained to two simultaneous sinusoidally amplitude modulated (sAM) tones from young and aged Fischer-344 rats. One was held at a fixed suprathreshold sound level (sAM1FL) while the second varied in sound level (sAM2VL) and carrier frequency. EFR amplitudes to sAM1FL in the young decreased with signal-to-noise ratio (SNR), and this reduction was more pronounced when the sAM2VL carrier frequency was spectrally separated from sAM1FL. Aged animals showed similar trends, while having decreased overall response amplitudes compared to the young. These results were replicated using an established computational model of the auditory nerve. The trends observed in the EFRs were shown to be due to the contributions of the low-frequency tails of high-frequency neurons, rather than neurons tuned to the sAM1FL carrier frequency. Modeling changes in threshold and neural loss reproduced some of the changes seen with age, but accuracy improved when combined with an additional decrease representing synaptic loss of auditory nerve neurons. Sound segregation in this case derives primarily from peripheral processing, regardless of age. Contributions by more central neural mechanisms are likely to occur only at low SNRs. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 30% |
| Researcher | 8 | 20% |
| Student > Master | 6 | 15% |
| Other | 3 | 8% |
| Student > Bachelor | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 4 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 10 | 25% |
| Neuroscience | 7 | 18% |
| Agricultural and Biological Sciences | 4 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Psychology | 3 | 8% |
| Other | 7 | 18% |
| Unknown | 6 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2016.
All research outputs
#16,067,622
of 23,849,058 outputs
Outputs from Journal of the Association for Research in Otolaryngology
#264
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Outputs of similar age
#179,862
of 301,012 outputs
Outputs of similar age from Journal of the Association for Research in Otolaryngology
#4
of 9 outputs
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