↓ Skip to main content

Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts

Overview of attention for article published in Nature Communications, February 2016
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Citations

dimensions_citation
153 Dimensions

Readers on

mendeley
126 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts
Published in
Nature Communications, February 2016
DOI 10.1038/ncomms10740
Pubmed ID
Authors

Liang Ma, Zehua Chen, Da Wei Huang, Geetha Kutty, Mayumi Ishihara, Honghui Wang, Amr Abouelleil, Lisa Bishop, Emma Davey, Rebecca Deng, Xilong Deng, Lin Fan, Giovanna Fantoni, Michael Fitzgerald, Emile Gogineni, Jonathan M. Goldberg, Grace Handley, Xiaojun Hu, Charles Huber, Xiaoli Jiao, Kristine Jones, Joshua Z. Levin, Yueqin Liu, Pendexter Macdonald, Alexandre Melnikov, Castle Raley, Monica Sassi, Brad T. Sherman, Xiaohong Song, Sean Sykes, Bao Tran, Laura Walsh, Yun Xia, Jun Yang, Sarah Young, Qiandong Zeng, Xin Zheng, Robert Stephens, Chad Nusbaum, Bruce W. Birren, Parastoo Azadi, Richard A. Lempicki, Christina A. Cuomo, Joseph A. Kovacs

Abstract

Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal pathogen. Here we report near complete genome assemblies for three Pneumocystis species that infect humans, rats and mice. Pneumocystis genomes are highly compact relative to other fungi, with substantial reductions of ribosomal RNA genes, transporters, transcription factors and many metabolic pathways, but contain expansions of surface proteins, especially a unique and complex surface glycoprotein superfamily, as well as proteases and RNA processing proteins. Unexpectedly, the key fungal cell wall components chitin and outer chain N-mannans are absent, based on genome content and experimental validation. Our findings suggest that Pneumocystis has developed unique mechanisms of adaptation to life exclusively in mammalian hosts, including dependence on the lungs for gas and nutrients and highly efficient strategies to escape both host innate and acquired immune defenses.

X Demographics

X Demographics

The data shown below were collected from the profiles of 34 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 126 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 25%
Student > Ph. D. Student 25 20%
Student > Master 12 10%
Student > Doctoral Student 7 6%
Student > Bachelor 7 6%
Other 25 20%
Unknown 19 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 32 25%
Agricultural and Biological Sciences 30 24%
Medicine and Dentistry 19 15%
Immunology and Microbiology 12 10%
Veterinary Science and Veterinary Medicine 3 2%
Other 11 9%
Unknown 19 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 92. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2020.
All research outputs
#408,597
of 23,576,969 outputs
Outputs from Nature Communications
#6,893
of 49,146 outputs
Outputs of similar age
#7,749
of 299,950 outputs
Outputs of similar age from Nature Communications
#149
of 878 outputs
Altmetric has tracked 23,576,969 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,146 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,950 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 878 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.