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Mendeley readers
Attention Score in Context
| Title |
Altered expression of p53, but not Rb, is involved in canine prostatic carcinogenesis
|
|---|---|
| Published in |
Research in Veterinary Science, February 2016
|
| DOI | 10.1016/j.rvsc.2016.02.022 |
| Pubmed ID | |
| Authors |
Simone Pagliarone, Luca Frattone, Valeria Pirocchi, Leonardo Della Salda, Chiara Palmieri |
| Abstract |
Abnormalities in the retinoblastoma (Rb) and p53 tumour suppressor gene have been frequently detected in human and canine cancers, but never investigated in canine prostate cancer, considered a good model for the advanced and aggressive androgen-resistant prostate cancer in men. Therefore, the aim of this study was to evaluate the immunohistochemical expression of Rb and p53 in 6 normal canine prostates, 15 canine prostates with benign prostatic hyperplasia (BPH) and 10 prostatic carcinomas (PCs). In all normal samples, p53 was expressed in low number of epithelial cells, while a greater number of positive cells were observed in BPH and PC. The mean number of positive cells was statistically significantly higher in PCs than normal and hyperplastic prostates. A cytoplasmic or nucleo-cytoplasmic staining was observed in 5 out of 10 PCs. Rb protein was expressed in high number of normal, hyperplastic and neoplastic cells without a statistically significant differences. Considering that Rb is frequently lost in human prostate cancer, we suggest that Rb is not involved in canine prostatic carcinogenesis. On the other hand, the increased expression of p53 that corresponds to genetic defects in the p53 gene may be associated with the malignant growth of canine prostate cancer, conferring an apoptosis-resistant phenotype. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 6 | 21% |
| Researcher | 5 | 17% |
| Other | 4 | 14% |
| Student > Master | 4 | 14% |
| Student > Doctoral Student | 3 | 10% |
| Other | 5 | 17% |
| Unknown | 2 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 17 | 59% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Business, Management and Accounting | 1 | 3% |
| Unspecified | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 4 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2016.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Research in Veterinary Science
#1,468
of 2,352 outputs
Outputs of similar age
#231,413
of 313,045 outputs
Outputs of similar age from Research in Veterinary Science
#15
of 40 outputs
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So far Altmetric has tracked 2,352 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
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