| Title |
Lamotrigine in the Treatment of Unipolar Depression with and Without Comorbidities: A Literature Review
|
|---|---|
| Published in |
Psychiatric Quarterly, February 2012
|
| DOI | 10.1007/s11126-012-9208-4 |
| Pubmed ID | |
| Authors |
Adam Daniel Zavodnick, Rizwan Ali |
| Abstract |
To review the available data behind the use of lamotrigine in unipolar depression and common comorbid conditions. A PubMed based literature review was conducted using keywords related to lamotrigine, depression, anxiety, post traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and personality disorders. A large number of trials using lamotrigine for unipolar depression and various comorbid conditions were reviewed. A major limitation behind the majority of studies was a limited course of the treatment phase. The most robust data was found among studies that followed patients for over 8 weeks, and used higher dosages. Patients with comorbid anxiety states appeared to benefit. Patients with borderline personality disorder also appeared to benefit. The benefits of lamotrigine in unipolar depression have been inconsistently noted in a number of studies. This is due in part to short treatment phases, atypical domains of benefit and different patient populations across studies. Patients with more treatment-resistance, comorbid anxiety and borderline personality disorder may be more able to benefit from lamotrigine. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 15% |
| Student > Doctoral Student | 8 | 15% |
| Researcher | 6 | 11% |
| Student > Postgraduate | 6 | 11% |
| Student > Bachelor | 5 | 9% |
| Other | 14 | 26% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 33% |
| Psychology | 12 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Neuroscience | 3 | 6% |
| Agricultural and Biological Sciences | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 8 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2012.
All research outputs
#15,241,801
of 22,662,201 outputs
Outputs from Psychiatric Quarterly
#416
of 621 outputs
Outputs of similar age
#164,081
of 248,330 outputs
Outputs of similar age from Psychiatric Quarterly
#5
of 7 outputs
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